静脉补液对新生儿高胆红素血症的临床疗效和安全性评价  

Evaluation of Clinical Efficacy and Safety of Intravenous Rehydration on Neonatal Hyperbilirubinemia

作　　者：郭晓婷 葛琪琦 杨坤[1] 周磊磊 宋玉娥[1] GUO Xiaoting;GE Qiqi;YANG Kun;ZHOU Leilei;SONG Yu’e(Department of Neonatology,The First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou Inner Mongolia 014000,China)

机构地区：[1]内蒙古科技大学包头医学院第一附属医院新生儿科,内蒙古包头014000

出　　处：《中国卫生标准管理》2022年第10期110-113,共4页China Health Standard Management

摘　　要：目的探究静脉补液对新生儿高胆红素血症的临床疗效和安全性。方法对本院新生儿科2019年1—12月收治的80例高胆红素血症的新生儿进行回顾性研究,对2019年1—6月收治的40名患儿作为对照组,予冷光源蓝光照射、碱性液补充及双歧四联活菌片口服;对2019年7—12月收治的40名患儿作为治疗组,治疗组在对照组的基础上加用静脉补液,治疗后观察两组的治疗有效率、不良反应发生率、住院时间及住院费用。结果有效率及不良反应发生率在治疗组和对照组之间比较,差异无统计学意义(P>0.05);治疗组的总胆红素(total bilirubin,TB)及间接胆红素(indirect bilirubin,IB)下降情况明显优于对照组,差异有统计学意义(P<0.05);治疗前直接胆红素(direct bilirubin,DB)在治疗组明显高于对照组,差异有统计学意义(P<0.05),而治疗后DB在两组间差异无统计学意义(P>0.05);治疗组的住院时间较对照组明显缩短,差异有统计学意义(P<0.05);治疗组与对照组相比,住院费用差异无统计学意义(P>0.05)。结论在对新生儿高胆红素血症常规治疗的基础上给予静脉补液与常规治疗相比,疗效一致,除此之外,还能缩短患儿住院时间,不存在治疗安全性问题,不增加住院费用,值得推广。Objective To explore the clinical efficacy and safety of intravenous rehydration on neonatal hyperbilirubinemia.Methods A total of 80 cases of neonatal hyperbilirubinemia treated in our hospital from January to December 2019 were retrospectively studied.40 cases of neonatal hyperbilirubinemia treated in our hospital from January to June 2019 were taken as the control group,which were given cold light blue light irradiation,alkaline solution supplement and bifidobacterium tetravaccine tablets orally;40 cases of neonatal hyperbilirubinemia treated in our hospital from July to December 2019 were taken as the treatment group,which were treated with intravenous rehydration on the basis of the control group.After treatment,the effective rate,incidence of adverse reactions,length of hospital stay and hospitalization expenses of the two groups were observed.Results There was no difference in the effective rate and the incidence of adverse reactions between the treatment group and the control group(P>0.05);the decrease of total bilirubin(TB)and indirect bilirubin(IB)in the treatment group was significantly better than that in the control group(P<0.05);direct bilirubin(DB)in the treatment group was significantly higher than that in the control group before treatment,the difference was statistically significant(P<0.05),and DB after treatment in the two groups had little difference,the difference was not statistically significant(P>0.05);compared with the control group,the hospitalization time of the treatment group was significantly shorter,the difference was statistically significant(P<0.05);compared with the control group,the hospitalization expenses of the treatment group did not increase significantly,the difference was not statistically significant(P>0.05).Conclusion On the basis of routine treatment of neonatal hyperbilirubinemia,intravenous rehydration has the same curative effect compared with routine treatment.In addition,it can shorten the hospitalization time of children,there is no problem of treatment safety,an

关 键 词：静脉补液 新生儿高胆红素血症 临床疗效 安全性 治疗有效率 不良反应 

分 类 号：R452[医药卫生—治疗学]