Anti-inflammatory effects of Abelmoschus manihot(L.)Medik.on LPS-induced cystitis in mice:potential candidate for cystitis treatment based on classic use  

作　　者：ZHOU Su FAN Kai-Kai GU Li-Fei YU Bo-Yang CHAI Cheng-Zhi 

机构地区：[1]Jiangsu Key Laboratory of TCM Evaluation and Translational Research,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China [2]Research Center for Traceability and Standardization of TCMs,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China

出　　处：《Chinese Journal of Natural Medicines》2022年第5期321-331,共11页中国天然药物（英文版）

基　　金：supported by the“Double First-Class”University project(CPU2018GF06).

摘　　要：Abelmoschus manihot(L.)Medik.(A.manihot)is a traditional Chinese herbal medicine with a variety of pharmacological properties.It was first recorded in Jiayou Materia Medica dating back to the Song dynasty to eliminate urinary tract irritation by clearing away heat and diuretic effect.However,its pharmacological action on urinary tract infections has not been investigated.The present study aims to evaluate the anti-inflammatory activity of A.manihot on a mouse model of lipopolysaccharide(LPS)-induced cystitis.The results showed that A.manihot decreased white blood cell(WBC)count in urine sediments of the cystitis mice,alleviated bladder congestion,edema,as well as histopathological damage,reduced the expression levels of tumor necrosis factor-α,interleukin-6,and interleukin-1βsimultaneously.Moreover,A.manihot administration significantly downregulated the expression levels of TLR4,MYD88,IκBα,p-IκBα,NF-κB p65,and p-NF-κB p65 in LPS-induced cystitis mice.These findings demonstrated the protective effect of A.manihot against LPS-induced cystitis,which is attributed to its anti-inflammatory profile by suppressing TLR4/MYD88/NF-κB pathways.Our results suggest that A.manihot could be a potential candidate for cystitis treatment.

关 键 词：Abelmoschus manihot(L.)Medik.(A.manihot) CYSTITIS Lipopolysaccharide(LPS) Inflammation TLR4/MYD88/NF-κB 

分 类 号：R91[医药卫生—药学] R694.3