重组人生长激素联合营养支持对特发性矮小症患儿身体构成和血清IGF-1水平的影响  

Effects of Recombinant Human Growth Hormone Combined with Nutritional Support on Body Compositions and Level of Serum IGF-1 in Children with Idiopathic Short Stature

作　　者：田金富 李芳 赵娜 元芳芳 陈惠军 TIAN Jin-fu;LI Fang;ZHAO Na;YUAN Fang-fang;CHEN Hui-jun(Department of Pediatric Rehabilitation,Xinxiang Central Hospital(The Fourth Clinical College of Xinxiang Medical College),Xinxiang 453099,Henan Province,China)

机构地区：[1]新乡市中心医院(新乡医学院第四临床学院)小儿康复科,河南新乡453099

出　　处：《罕少疾病杂志》2022年第7期105-106,112,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨重组人生长激素联合营养支持对特发性矮小症(ISS)患儿身体构成和血清胰岛素样生长因子(IGF-1)水平的影响。方法选取2019年9月至2020年9月在我院治疗的70例ISS患儿,简单随机分为观察组和对照组,每组各35例。对照组采用营养支持的方法治疗儿童ISS,观察组在对照组基础上联合应用重组人生长激素,两组患儿均持续治疗6个月。分别于治疗前后,比较两组患儿身高、体重、骨龄、生长速度的变化;采用酶联免疫吸附法(ELISA)方法检测治疗前后血清IGF-1和胰岛素样生长因子结合蛋白-3(IGFBP-3)水平变化;比较两组患儿发生不良反应的情况;使用健康调查简表SF-36量表比较两组患儿生活质量。结果观察组患儿身高、体重、骨龄、生长速度的变化显著优于对照组(P<0.05);观察组和对照组患者治疗后血清IGF-1和IGFBP-3水平均较治疗前有升高,但观察组患者升高水平更明显(P<0.05);观察组和对照组患者治疗后头痛、空腹血糖水平增高、甲状腺功能异常、肝肾功能损坏等不良反应的发生率无明显差异(P>0.05);观察组生活质量评分明显高于对照组(P>0.05)。结论重组人生长激素联合营养支持治疗可以明显升高血清IGF-1水平,改善ISS儿童的身体构成,提高生长速度。Objective To explore the effects of recombinant human growth hormone(rhGH)combined with nutritional support on body compositions and level of serum insulin-like growth factor 1(IGF-1)in children with idiopathic short stature(ISS).Methods A total of 70 children with ISS treated in the hospital were enrolled between September 2019 and September 2020.According to simple random grouping method,they were divided into observation group and control group,35 cases in each group.The control group was treated with nutritional support,while observation group was treated with rhGH on basis of control group.Both groups were continuously treated for 6 months.Before and after treatment,changes in height,weight,bone age and growth rate between the two groups were compared.The changes in levels of serum IGF-1 and insulinlike growth factor binding protein-3(IGFBP-3)before and after treatment were detected by enzyme-linked immunosorbent assay(ELISA).The occurrence of adverse reactions between the two groups was compared.And quality of life between the two groups was compared by 36-item shot-form health status survey(SF-36).Results The changes of height,weight,bone age and growth rate in observation group were significantly better than those in control group(P<0.05).After treatment,levels of serum IGF-1 and IGFBP-3 in both groups were increased,which were significantly higher in observation group than control group(P<0.05).After treatment,there was no significant difference in the incidence of adverse reactions(headache,increase of fasting blood glucose,abnormal thyroid function,liver-kidney damage)between the two groups(P>0.05).The quality of life score in observation group was significantly higher than that in control group(P>0.05).Conclusion The rhGH combined with nutritional support can significantly increase level of serum IGF-1,improve body compositions and accelerate growth rate in ISS children.

关 键 词：重组人生长激素 营养支持 儿童特发性矮小症 胰岛素样生长因子 

分 类 号：R72[医药卫生—儿科] R459.1[医药卫生—临床医学]