慢性乙型肝炎患者免疫球蛋白检验的临床价值  

Clinical Value of Immunoglobulin Test in Patients with Chronic Hepatitis B

作　　者：徐杨 赵阳 郭慧 XU Yang;ZHAO Yang;GUO Hui(Dalian Friendship Hospital,Dalian 116001,China)

机构地区：[1]大连市友谊医院,辽宁大连116001

出　　处：《中国医药指南》2022年第17期117-119,共3页Guide of China Medicine

摘　　要：目的研究免疫球蛋白检验在慢性乙型肝炎患者中的临床应用价值,并据此展开对比分析,以期为临床相关工作的开展提供一定参考。方法选择2016年11月至2018年11月我院接收的100例慢性乙型肝炎患者为观察对象,根据病情危险程度将患者分为慢性乙型肝炎组(60例)和慢性重型乙型肝炎组(40例),选择同期50名到我院进行体检的健康人员作为对照组,对所有研究对象进行免疫球蛋白检测,统计和对比改善和恶化2种状态下患者的免疫功能及病情变化情况,比较3组研究对象免疫球蛋白检验结果。结果改善组慢性乙型肝炎患者的IgG、IgM、IgA、TBI指标明显高于恶化组慢性乙型肝炎患者,PTA指标则低于恶化组慢性乙型肝炎患者,差异有统计学意义(t=7.63、11.25、3.69、4.20、3.45,P<0.05);慢性重型乙型肝炎组和慢性乙型肝炎组的IgG、IgM、IgA指标明显高于对照组,差异有统计学意义(t=25.48、33.34、39.307,P<0.05)。结论免疫球蛋白检验在慢性乙型肝炎患者中有着显著的临床价值。Objective To study the clinical value of immunoglobulin test in patients with chronic hepatitis B,and to carry out comparative analysis,in order to provide some reference for clinical work.Methods From November 2016 to November 2018,100 patients with chronic hepatitis B who were admitted to our hospital in recent two years were selected as the observation objects,they were divided into chronic hepatitis B group(60 cases)and chronic severe hepatitis B group(40 cases),and then 50 health personnel who came to our hospital for physical examination at the same time were selected as the control group.All research subjects were tested for immunoglobulin,and the immune function and disease changes of patients in two states of improvement and deterioration were counted and compared,and the results of immunoglobulin tests of the three groups of subjects were compared.Results The indexes of IgG,IgM,IgA and TBI in the improvement group were significantly higher than those in the worsening group,while the PTA indexes were lower than those in the worsening group,the differences were statistically significant(t=7.63,11.25,3.69,4.20,3.45,P<0.05).The indexes of IgG,IgM and IgA in chronic severe hepatitis B group and chronic hepatitis B group were significantly higher than those in control group,the differences were statistically significant(t=25.48,33.34,39.307,P<0.05).Conclusion Immunoglobulin test has significant clinical value in patients with chronic hepatitis B.

关 键 词：慢性乙型肝炎 慢性重型乙型肝炎 免疫球蛋白检验 

分 类 号：R512.62[医药卫生—内科学]