疼痛客观量化评估的必要性与研究进展  

The necessity and research progress of objective quantitative assessment of pain

作　　者：李丽旋 蒋昌宇 罗裕辉 孙武平 秋云海[3] 张强 彭莉萍 廖翔 肖礼祖 王海宁[4] 樊碧发[4] 熊东林 LI Lixuan;JIANG Changyu;LUO Yuhui;SUN Wuping;QIU Yunhai;ZHANG Qiang;PENG Liping;LIAO Xiang;XIAO Lizu;WANG Haining;FAN Bifa;XIONG Donglin(Guangdong Medical University,Zhanjiang 524023,China;Department of Pain Medicine,Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen 518052,China;Research Center for Neural Engineering,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518052,China;Department of Pain Management,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]广东医科大学,湛江524023 [2]华中科技大学协和深圳医院疼痛科,深圳518052 [3]中国科学院深圳先进技术研究院神经工程研究中心,深圳518052 [4]中日友好医院疼痛科,北京100029

出　　处：《中国疼痛医学杂志》2022年第5期324-330,共7页Chinese Journal of Pain Medicine

基　　金：国家自然科学基金(82171221,82171378,32100809);深圳市科技创新委员会基础研究面上项目(JCYJ20210324112202006);深圳市医疗卫生三名工程引进“中日友好医院樊碧发教授疼痛医学团队”项目(SZSM202103018)。

摘　　要：疼痛的评估量化是疼痛医学发展的重要基石,但目前临床常用的评估方法以主观判断为主,未能精确量化客观存在的疼痛。因此,疼痛的客观量化评估已经成为疼痛医学界亟待解决的难题,但由于急性疼痛与慢性疼痛的形成机制不同,不同类型的慢性疼痛发病机制也差异巨大,诸多脑区均参与疼痛的感知与调节,神经系统以外的其他系统也参与病理性疼痛的形成,导致客观准确的量化评估方法仍在艰难的探索之中。本文就近年来相关的研究进展进行探讨,重点围绕生物电进行叙述,以期为未来疼痛客观量化评估提供一定的科学依据和参考。The objective and quantitative assessment of pain is an important cornerstone of the development of pain medicine,but the commonly used methods are relatively subjective,and cannot accurately and quantitatively reflect the objective pain.It is still a big challenge to explore accurate and objective assessment methods currently,since the different mechanisms of acute pain and chronic pain,the pathological mechanisms of different types of chronic pain is also heterogeneous,many brain regions are involved in pain perception and other non-neural systems are also involved in the formation of pathological pain.This review discussed the relevant research progress in recent years,focusing on bioelectricity,to inspire the establishment of objective and quantitative methods for pain assessment in the future.

关 键 词：疼痛 客观量化评估 脑电图 功能磁共振 机器学习 

分 类 号：R402[医药卫生—临床医学]