TSLP、Bach2及IL⁃9在嗜酸性粒细胞浸润鼻息肉中的表达及临床意义  

Expression and clinical significance of TSLP,Bach2,and IL⁃9 in eosinophilic infiltrating nasal polyps

作　　者：魏鑫鑫[1] 李晓玲 黄维平[1] 尹中普[1] WEI Xinxin;LI Xiaoling;HUANG Weiping;YIN Zhongpu(Department of Otolaryngology Head and Neck surgery,Nanyang Central Hospital,Nanyang,Henan,China,473000)

机构地区：[1]南阳市中心医院耳鼻咽喉头颈外科,河南南阳473000

出　　处：《分子诊断与治疗杂志》2022年第5期887-890,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省科技攻关项目(16210213135)。

摘　　要：目的探讨胸腺基质淋巴细胞生成素(TSLP)、BTB与CNC同源基因2(Bach2)、白细胞介素⁃9(IL⁃9)在嗜酸性粒细胞浸润鼻息肉(Eos NPs)中的表达情况及临床意义。方法收集2017年2月至2019年2月于南阳市中心医院行鼻内镜手术的85例Eos NPs患者的85份下鼻甲组织(实验组),根据Eos NPs分期标准分为:Ⅱ型2期37例,Ⅱ型3期48例;同时选取52例行单纯鼻中隔矫正术患者的52份下鼻甲组织(对照组)。比较不同组织、分期的TSLP、Bach2、IL⁃9水平,绘制ROC曲线,分析TSLP、Bach2、IL⁃9三者单一检测及联合检测对Eos NPs诊断的灵敏度、特异度及AUC数值。结果实验组TSLP、IL⁃9水平明显高于对照组,Bach2阳性表达率明显低于对照组,差异有统计学意义(P<0.05)。在不同分期中,II型3期的TSLP、IL⁃9水平明显高于Ⅱ型2期,Bach2阳性表达率明显低于Ⅱ型2期,差异有统计学意义(P<0.05)。Pearson相关性显示,TSLP、IL⁃9与Eos NPs分期呈正相关(R=0.625,P=0.036;R=0.893,P=0.027),Bach2与Eos NPs分期呈负相关(R=-0.832,P=0.049)。TSLP、Bach2、IL⁃9三者联合检测诊断Eos NPs的灵敏度、特异度及AUC分别为94.52%、90.66%、0.926,显著高于单一检测(P<0.05)。结论TSLP、Bach2、IL⁃9的表达水平与Eos NPs有关,联合三者检测诊断Eos NPs的意义重大。Objective To explore the expression and clinical significance of thymic stromal lymphopoietin(TSLP),BTB and CNC homolog 2(Bach2),and interleukin⁃9(IL⁃9)in eosinophilic infiltrating nasal polyps(Eos NPs).Methods 85 inferior turbinate tissues from 85 Eos NPs patients who underwent endoscopic sinus surgery in Nanyang Central Hospita from February 2017 to February 2019 were collected(experimental group).According to the Eos NPs staging standard,they were divided into:37 cases of type II stage 2 and 48 cases of type II stage 3.At the same time,52 inferior turbinate tissues of 52 cases who underwent simple septal correction surgery were also collected(control group).The levels of TSLP,Bach2,and IL⁃9 in different tissues and stages were compared,and the ROC curve was drawn to analyze the sensitivity,specificity and AUC value of TSLP,Bach2,and IL⁃9 single detection and combined detection for the diagnosis of Eos NPs.Results The levels of TSLP and IL⁃9 in the experimental group were significantly higher than those in the control group,the positive expression rate of Bach2 was significantly lower than in the control group,and the difference was statistical significance(P<0.05).In different stages,the levels of TSLP and IL⁃9 in type II stage 3 were significantly higher than those in type II stage 2,and the positive expression rate of Bach2 was significantly lower than that in type II stage 2(P<0.05).Pearson correlation showed that TSLP and IL⁃9 were positively correlated with Eos NPs staging(R=0.625,P=0.036;R=0.893;P=0.027),Bach2 was negatively correlated with Eos NPs staging(R=-0.832,P=0.049).The sensitivity,specificity and AUC of TSLP,Bach2 and IL⁃9 combined detection in the diagnosis of Eos NPs were 94.52%,90.66%and 0.926,respectively,which were significantly higher than those of the three single detection(P<0.05).Conclusion The expression levels of TSLP,Bach2,and IL⁃9 are related to Eos NPs,and the combined detection of the three is of great significance in the diagnosis of Eos NPs.

关 键 词：TSLP Bach2 IL⁃9 嗜酸性粒细胞 鼻息肉 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]