关注新型冠状病毒感染相关肝损伤  

Concerns about COVID-19-associated liver injury

作　　者：俞晓琦 张欣欣[1] Yu Xiaoqi;Zhang Xinxin(Department of Infectious Diseases,Research Laboratory of Clinical Virology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院感染科临床病毒研究室,上海200025

出　　处：《中华肝脏病杂志》2022年第5期473-476,共4页Chinese Journal of Hepatology

基　　金：上海市科委重点项目(20JC1410200)。

摘　　要：新型冠状病毒肺炎患者经常可伴有肝损伤,且可能与疾病严重程度相关。新型冠状病毒感染相关肝损伤的发病机制与多种因素相关,除了与患者原有的基础肝脏疾病有关外,病毒感染胆管上皮细胞、全身性炎症反应及低氧性肝损伤等可能都是导致肝损伤的原因。在患者的治疗过程中需要密切监测肝功能,并注意药物性肝损伤的发生。Patients infected with 2019-nCoV/SARS-CoV-2 are usually accompanied with liver injury,which may correlates with the severe forms of the disease.The pathogenesis of COVID-19-associated liver injury is not only related to the underlying liver diseases,viral cholangitis,systemic inflammatory response,and hypoxic liver injury,but also to multiple factors that lead to liver injury in patients.Therefore,during the course of treatment,the patient's liver function should be closely monitored,and attention should be paid to the occurrence of drug-induced liver injury.

关 键 词：新型冠状病毒 严重急性呼吸道综合征冠状病毒2型 新型冠状病毒肺炎 肝损伤 肝功能 

分 类 号：R563.1[医药卫生—呼吸系统] R575[医药卫生—内科学]