慢性HBV感染者血清HBV RNA检测及临床应用的专家共识  

Expert consensus on measurement and clinical application of serum HBV RNA in patients with chronic HBV infection

作　　者：刘燕娜 樊蓉[2] 杨瑞锋[3] 刘诗 王杰[1] 廖昊 仇超 邓芮 黄鸿鑫 胡鹏[6] 郑素军[7] 张文宏 陈香梅[1] 陈红松[3] 孙剑[2] 鲁凤民[1,3] 中华医学会肝病学分会基础医学与实验诊断协作组 Liu Yanna;Fan Rong;Yang Ruifeng;Liu Shi;Wang Jie;Liao Hao;Qiu Chao;Deng Rui;Huang Hongxin;Hu Peng;Zheng Sujun;Zhang Wenhong;Chen Xiangmei;Hongsong Chen;Sun Jian;Lu Fengmin;Cooperative Group of Basic Research and Experimental Diagnosis of Liver(Department of Microbiology&Infectious Disease Center,Peking University Health Science Center,Beijing 100191,China;Guangdong Provincial Institute of Liver Disease,Guangdong Provincial Key Laboratory of Viral Hepatitis Research,Department of Infectious Diseases,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Peking University People's Hospital,Peking University Hepatology Institute,Beijing 100044,China;Department of Clinical Laboratory,Shenzhen Third People's Hospital,Southern University of Science and Technology,National Clinical Research Center for Infectious Diseases,Shenzhen 518112,China;Department of Infectious Diseases,Huashan Hospital Affiliated to Fudan University,Shanghai 200040,China;Department of Infectious Diseases,the Second Affiliated Hospital of Chongqing Medical University,Institute for Viral Hepatitis of Chongqing Medical University,Chongqing 400010,China;Liver Diseases Center,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China;不详)

机构地区：[1]北京大学基础医学院病原生物学系暨感染病研究中心,北京100191 [2]南方医科大学南方医院感染内科广东省病毒性肝炎研究重点实验室广东省肝脏疾病研究所,广州510515 [3]北京大学人民医院北京大学肝病研究所,北京100044 [4]国家感染性疾病临床研究中心南方科技大学第二附属医院(深圳市第三人民医院)检验医学部,深圳518112 [5]复旦大学附属华山医院感染科,上海200040 [6]重庆医科大学附属第二医院感染病科重庆医科大学病毒性肝炎研究所,重庆400010 [7]首都医科大学附属北京佑安医院肝病中心,北京100069 [8]不详

出　　处：《中华肝脏病杂志》2022年第5期505-512,共8页Chinese Journal of Hepatology

摘　　要：自1996年在慢性乙型肝炎患者的外周血中发现游离的乙型肝炎病毒(HBV)RNA以来,越来越多的研究致力于阐明血清HBV RNA的生物学特征和临床应用价值。该共识总结了血清HBV RNA存在形式、定量检测方法及目前临床应用的研究进展,并针对定量检测的靶标区域、检测结果和临床应用作出推荐意见,以期更好地将该指标用于临床慢性HBV感染者的管理。Since the discovery of circulating hepatitis B virus(HBV)RNA in the peripheral blood of patients with chronic hepatitis B in 1996,a growing number of studies have focused on clarifying the biological characteristics and clinical application value of serum HBV RNA.This consensus mainly summarizes the research progress of serum HBV RNA existing profiles,quantitative detection methods,and current clinical applications.In order to better apply this indicator for the clinical management of patients with chronic HBV infection,recommendations on quantitative detection target regions,detection results,and clinical applications are put forward.

关 键 词：慢性乙型肝炎 乙型肝炎病毒 脱氧核糖核酸 检测 临床应用 

分 类 号：R512.62[医药卫生—内科学]