MXenes的制备、性质及其在肿瘤诊疗中的研究进展  

Research Progress on MXenes: Preparation, Property and Application in Tumor Theranostics

作　　者：白志强 赵璐[2] 白云峰[2] 冯锋[1,2] BAI Zhiqiang;ZHAO Lu;BAI Yunfeng;FENG Feng(School of Chemistry and Material Science,Shanxi Normal University,Linfen 041004,China;Shanxi Provincial Key Laboratory of Chemical Biosensing,College of Chemistry and Chemical Engineering,Shanxi Datong University,Datong 037009,China)

机构地区：[1]山西师范大学化学与材料科学学院,临汾041004 [2]山西大同大学化学与化工学院,化学生物传感山西省重点实验室,大同037009

出　　处：《无机材料学报》2022年第4期361-375,共15页Journal of Inorganic Materials

基　　金：国家自然科学基金(21975146);山西省高等学校科学研究优秀成果培育项目(2020KJ023);山西省省筹资金资助回国留学人员科研项目(2020-133);山西省高等学校科技创新项目(2021L368);山西师范大学研究生科技创新项目(2021XBY005)。

摘　　要：二维过渡金属碳化物、氮化物或碳氮化物(MXenes)已成为二维材料中一个新兴的热点领域。MXenes材料具有优异的电子传递性能、出色的光热转换性能、较高的比表面积、良好的生物相容性和低毒性等特点,在肿瘤诊疗中显示出良好的应用前景。本文简要总结了MXenes的制备方法,包括氢氟酸法、氟盐法、熔融盐法、碱辅助水热法和化学气相沉积法,及其稳定性、机械性质、光学性质和电学性质。重点综述了MXenes在肿瘤诊疗中的应用,包括光热治疗、多模式联合治疗、构建MXenes表面介孔材料的联合治疗和MXenes主动靶向联合治疗,以及建立MXenes诊断–治疗一体化平台。最后简要介绍了MXenes可能辅助肿瘤诊疗的其他特性及其应用,并阐述了MXenes在肿瘤诊疗中存在的挑战以及未来发展前景。Two-dimensional(2D) materials have brought about significant technological advancements in the field of biomaterials. Transition metal carbides and/or nitrides(MXenes) have a planar structure educed from their corresponding parent MAX phase by selective etching of ‘A’ and further delamination. Since the first MXene was reported in 2011,MXenes now comprise a rapidly growing family of 2D materials, having attracted extensive attention from researchers.Owing to their excellent electronic properties, outstanding photothermal conversion performance, high specific surface area, good biocompatibility, and low toxicity, MXenes have shown a good application prospect in tumor theranostics.This paper reviews substantive findings of the original researches focused on the preparation, property and application in tumor theranostics, including recent advances, challenges and future perspectives of MXenes. Firstly, we briefly summarize the preparation methods and property of MXenes, including HF acid method, fluoride salt method, molten salt method, alkali-assisted hydrothermal method, and chemical vapor deposition method, as well as stability,mechanical, optical, and electrical properties. Secondly, we focus on the application of MXenes in photothermal therapy and combined therapy. The usual method is to combine photothermal therapy, photodynamic therapy and chemotherapy to carry out multi-modal combined treatment of tumors. The combined therapy can also be improved by constructing surface nanopores of MXenes and loading chemotherapy drugs in them. Furthermore, enhanced MXenes synergistic therapeutic effect on tumor and reduced toxic side effects on normal tissue can be endued by active targeting technology. In addition, the preparation of multifunctional MXenes composite nanomaterials to obtain radiation treatment and imaging capabilities such as computed tomography scans and magnetic resonance imaging, can establish an integrated platform for MXenes theranostics. Finally, we briefly introduce other applications of MXenes

关 键 词：MXenes 制备方法 肿瘤诊疗 联合治疗 综述 

分 类 号：TQ174[化学工程—陶瓷工业]