芪参还五胶囊佐治气血亏虚型帕金森病临床观察  

Clinical Observation of Qishenhuanwu Capsules in the Adjuvant Treatment of Parkinson′s Disease with Qi-Blood Deficiency Pattern

作　　者：邱志新[1] 王雯[1] 郑建彪[1] 景海芳 QIU Zhixin;WANG Wen;ZHENG Jianbiao;JING Haifang(Department of Neurological RehabilitationⅡ,Cangzhou Hospital of Integrated TCM-WM·Hebei,Cangzhou,Hebei,China 061001)

机构地区：[1]河北省沧州中西医结合医院神经康复二科,河北沧州061001

出　　处：《中国药业》2022年第12期105-108,共4页China Pharmaceuticals

基　　金：河北省中医药管理局2019年度中医药类科研计划课题[2019296]。

摘　　要：目的探讨芪参还五胶囊佐治气血亏虚型帕金森病(PD)的临床疗效。方法选取医院2019年6月至2020年6月收治的PD患者100例,根据随机数字表法分为对照组和观察组,各50例。两组患者均予多巴丝肼片口服,观察组患者加服芪参还五胶囊,两组均连续治疗6个月。结果观察组的总有效率为96.00%,显著高于对照组的84.00%(P<0.05)。与对照组比较,观察组患者治疗后14天、6个月的统一帕金森病评分量表评分均显著降低,Hoehn-Yahr分期>1.5期的患者比例显著降低,简易精神状态检查量表评分均显著升高,匹兹堡睡眠质量指数量表评分均显著降低;神疲、乏力、自汗评分均显著降低;C反应蛋白,人帕金森病蛋白7水平均显著降低(P<0.05)。结论芪参还五胶囊辅助治疗气血亏虚型PD,可缓解患者的中医症状,提高其生活质量,改善血清生化指标水平。Objective To investigate the clinical efficacy of Qishenhuanwu Capsules in the adjuvant treatment of Parkinson′s disease(PD)with Qi-blood deficiency pattern.Methods A total of 100 patients with PD admitted to the hospital from June 2019 to June 2020 were selected and divided into the control group and the observation group according to the random number table method,with 50 cases in each group.The patients in the two groups were given Dobasazine Tablets orally,on this basis,the patients in the observation group were given Qishenhuanwu Capsules.Both groups were continuously treated for six months.Results The total effective rate in the observation group was 96.00%,which was significantly higher than 84.00%in the control group(P<0.05).After 14 d and 6 months of treatment,compared with those in the control group,the Unified Parkinson′s Disease Rating Scale(UPDRS)scores and the proportion of patients with Hoehn-Yahr staging>1.5 in the observation group decreased significantly,the Mini-Mental State Examination(MMSE)scores in the observation group increased significantly,the Pittsburgh sleep quality index(PSQI)scores in the observation group decreased significantly,the scores of mental fatigue,asthenia and spontaneous sweating in the observation group decreased significantly,while the levels of C-reactive protein(CRP)and human Parkinson′s disease protein 7(PARK7)in the observation group decreased significantly(P<0.05).Conclusion Qishenhuanwu Capsules in the adjuvant treatment of patients with PD complicated with Qi-blood deficiency pattern can relieve the traditional Chinese medicine syndromes,improve the patients′quality of life and the serum biochemical indexes.

关 键 词：芪参还五胶囊 气血亏虚 帕金森病 临床疗效 辅助治疗 

分 类 号：R969.4[医药卫生—药理学] R971[医药卫生—药学]