博来霉素联合电化学疗法治疗颜面部巨大皮肤癌临床观察  

Clinical Observation of Bleomycin Combined with Electrochemical Therapy in the Treatment of Giant Facial Skin Cancer

作　　者：张志东 魏海龙 林振海 陈吉柏 彭文 ZHANG Zhidong;WEI Hailong;LIN Zhenhai;CHEN Jibo;PENG Wen(Department of Thoracic and Heart Tumor Surgery,Danzhou People′s Hospital,Danzhou,Hainan,China 571700)

机构地区：[1]海南省儋州市人民医院胸心肿瘤外科,海南儋州571700

出　　处：《中国药业》2022年第12期108-112,共5页China Pharmaceuticals

基　　金：海南省卫生计生行业科研项目[16A200031]。

摘　　要：目的探讨博来霉素联合电化学疗法治疗颜面部巨大皮肤癌的临床效果。方法选取医院2016年1月至2018年10月医院收治的颜面部巨大皮肤癌(病灶基底宽>3 cm)患者137例,按随机数字表法分为联合组(45例)、电化学组(46例)及博来霉素组(46例)。电化学组患者单用电化学治疗,博来霉素组患者予注射用盐酸博来霉素治疗,联合组患者联用上述2种疗法。3组均治疗1个月,随访2年。结果治疗后,联合组及电化学组患者瘤体脱落时间、结痂时间均显著短于博来霉素组,结痂直径均显著小于博来霉素组(P<0.05);联合组患者疾病的总控制率(100.00%)及总缓解率(86.67%)显著高于电化学组(78.26%,58.70%)及博来霉素组(71.74%,45.65%)(P<0.05);3组患者不良反应发生率比较无显著差异(P>0.05);联合组患者随访期间复发率及再治疗率显著低于电化学组及博来霉素组(χ^(2)=5.829,6.604,7.143,4.828,P=0.016,0.010,0.008,0.028),电化学组与博来霉素组比较无显著差异(χ^(2)=0.019,0.006,P=0.892,0.936)。结论博来霉素联合电化学疗法治疗颜面部巨大皮肤癌近远期疗效均较好,且方法简便易行。Objective To investigate the clinical efficacy of bleomycin combined with electrochemical therapy in the treatment of giant facial skin cancer.Methods A total of 137 patients with giant facial skin cancer(lesion base width>3 cm)treated in the hospital from January 2016 to October 2018 were selected and divided into the combined group(45 cases),electrochemical group(46 cases)and bleomycin group(46 cases)according to the random number table method.The patients in the electrochemical group were treated with electrochemical therapy alone,patients in the bleomycin group were treated with Bleomycin Hydrochloride for Injection,and patients in the combined group were treated with electrochemical therapy combined with Bleomycin Hydrochloride for Injection.The three groups were treated for one month and followed up for two years.Results After treatment,the shedding time and scab forming time of tumor in the combined group and electrochemical group were significantly shorter than those in the bleomycin group,and the scab diameter in the combined group and the electrochemical group was significantly shorter than that in the bleomycin group(P<0.05).The total disease control rate and total remission rate in the combined group were 100.00%and 86.67%,which were significantly higher than 78.26%and 58.70%in the electrochemical group,71.74%and 45.65%in the bleomycin group(P<0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).The recurrence rate and retreatment rate in the combined group were significantly lower than those in the electrochemical group and the bleomycin group(χ^(2)=5.829,6.604,7.143,4.828,P=0.016,0.010,0.008,0.028),but there was no significant difference between the electrochemical group and the bleomycin group(χ^(2)=0.019,0.006,P=0.892,0.936).Conclusion Bleomycin combined with electrochemical therapy has good short-term and long-term efficacy in the treatment of giant facial skin cancer,and the method is simple and easy.

关 键 词：颜面部巨大皮肤癌 博来霉素 电化学治疗 联合疗法 近期疗效 远期疗效 

分 类 号：R969.4[医药卫生—药理学] R979.1[医药卫生—药学]