米卡芬净药品不良反应文献分析  

Adverse Drug Reactions Induced by Micafungin:A Literature Analysis

作　　者：柴双 展敬伦 刘晓东[1,2] CHAI Shuang;ZHAN Jinglun;LIU Xiaodong(Department of Pharmacy,Shengjing Hospital of China Medical University,Shenyang,Liaoning,China 110004;Department of the Second Clinical Pharmacy,School of Pharmacy,China Medical University,Shenyang,Liaoning,China 110001)

机构地区：[1]中国医科大学附属盛京医院药学部,辽宁沈阳110004 [2]中国医科大学药学院第二临床药学教研室,辽宁沈阳110001

出　　处：《中国药业》2022年第12期127-128,I0001,共3页China Pharmaceuticals

基　　金：中国医科大学附属盛京医院2020年40工程[M0723]。

摘　　要：目的促进米卡芬净的临床合理应用。方法检索2002年至2021年PubMed、中国期刊全文数据库、万方数据库、中国科技期刊数据库有关米卡芬净药品不良反应(ADR)的文献,利用监管活动医学词典(MedDRA)对米卡芬净单用及合并用药引起的ADR症状进行编码,并对ADR症状累及系统/器官进行分类。结果共纳入文献78篇,其中中文40篇,英文38篇;共收集米卡芬净ADR 1278例次,包括单独用药1268例次和合并用药10例次,累及消化、血液等系统;其临床表现复杂多样,其中以转氨酶升高、发烧、恶心呕吐为主。结论米卡芬净ADR可累及全身多个系统/器官,应注意加强对其监测(特别是某些特殊ADR的监测),以保证用药安全性和合理性。Objective To promote the rational clinical application of micafungin.Methods The studies related to adverse drug reactions(ADRs)induced by micafungin in PubMed,CJFD,WanFang and VIP databases from 2002 to 2021 were searched.The symptoms of ADRs induced by micafungin alone and combined with other drugs were coded by MedDRA,and the systems/organs involved in symptoms of ADRs were classified.Results Seventy-eight studies were included,including 40 studies in Chinese and 38 studies in English.A total of 1278 cases of ADRs induced by micafungin were collected,including ADRs induced by micafungin alone(1268 cases)and ADRs induced by micafungin combined with other drugs(10 cases),involving digestive and blood systems,and the clinical manifestations were complex and varied,among which elevated transaminases,fever,nausea and vomiting were the main ones.Conclusion ADRs induced by micafungin can affect many systems of the whole body.Physicians should pay attention to strengthen the monitoring of ADRs(especially some specific ADRs)to ensure the safety and rationality of medication.

关 键 词：米卡芬净 药品不良反应 文献分析 合理用药 

分 类 号：R978.5[医药卫生—药品] R969[医药卫生—药学]