2016—2020年淄博市学生结核潜伏感染现状及预防性服药情况分析  

Prevalence of latent tuberculosis infection and the use of preventive medication among students in Zibo city,2016—2020

作　　者：李源[1] 赵炫 刘洁[1] 金瑾 高风华[1] LI Yuan;ZHAO Xuan;LIU Jie;JIN Jin;GAO Feng-hua(Zibo Centers for Disease Control and Prevention,Zibo,Shandong 255026,China;不详)

机构地区：[1]淄博市疾病预防控制中心,山东255026 [2]山东省公共卫生临床中心

出　　处：《现代预防医学》2022年第11期1987-1991,1998,共6页Modern Preventive Medicine

基　　金：山东省医药卫生科技发展计划(2017WS788)。

摘　　要：目的 了解学生结核潜伏感染状况及预防性服药情况,为学校结核病防控提供科学依据。方法 收集“中国结核病管理信息”、“山东省学生健康体检管理系统”、结核病筛查年度报表数据,利用EpiData 3.1、 Excel 2016、SPSS 22.0软件统计分析。计数资料以“率”或“构成比”表示,采用χ^(2)检验进行比较。结果 共筛查170 143名学生,PPD阳性率17.77%,各年份PPD阳性率差异具有统计学意义(χ^(2)=274.998,P<0.001);男性与女性阳性率和强阳性率差异比较均无统计学意义(χ^(2)=1.476,P=0.224;χ^(2)=0.120,P=0.729);寄宿与非寄宿阳性率和强阳性率差异均有统计学意义(χ^(2)=1 039.468,P<0.001;χ^(2)=219.721,P<0.001);不同学历及生源地学生各年份阳性率(χ^(2)=193.277,P<0.001;χ^(2)=443.039,P<0.001)与强阳性率(χ^(2)=20.693,P<0.001;χ^(2)=438.292,P<0.001)差异均具有统计学意义。预防性服药率5.75%,“担心药物不良反应”拒绝者55.34%。结论 高中与大一新生是结核病筛查重点,对强阳性者要重点科普预防服药相关知识,提高学生对预防性服药接受度。Objective To investigate the status of latent tuberculosis infection and preventive medicine in students,and to provide scientific basis for tuberculosis prevention and control in schools.Methods The data of China Tuberculosis Management Information,Shandong Province Student Health Examination Management System and tuberculosis screening annual report were collected and analyzed by EpiData 3.1,Excel 2016 and SPSS 22.0.The count data were expressed as rate or constituent ratio and were compared by chi-square(χ~2) test.Results A total of 170,143 students were screened,and the positive rate of PPD was 17.77%.The positive rate of PPD in each year was statistically significant(χ~2=274.998,P<0.001).There were no significant differences in positive rate and strong positive rate between males and females(χ~2=1.476,P=0.224;χ2=0.120,P=0.729).There were statistically significant differences in positive rate and strong positive rate between boarders and non-boarders(χ~2=1,039.468,P<0.001;χ~2=219.721,P<0.001).There were significant differences in positive rate(χ~2=193.277,P<0.001;χ~2=443.039,P<0.001) and strong positive rate(χ~2=20.693,P<0.001;χ~2=438.292,P<0.001)among students with different educational background and origin.The rate of preventive medication taking was 5.75%,and 55.34% of those who refused because of worrying about adverse drug reactions.Conclusion High school students and freshmen are the focus of TB screening,and the knowledge related to preventive medicine should be popularized for those who are strongly positive,and the acceptance of preventive medicine should be improved.

关 键 词：学生 结核 潜伏感染 预防性服药 

分 类 号：R179[医药卫生—妇幼卫生保健]