INSURE技术与LISA技术治疗早产儿呼吸窘迫综合征的效果  

Therapeutic efficacy of INSURE technology and LISA technology in the treatment of neonatal respiratory distress syndrome

作　　者：邓笑梅 雷仲洋 DENG Xiaomei;LEI Zhongyang(Department of Neonatology,Panyu Maternal and Child Health Hospital,Guangdong,Guangzhou 511400,China)

机构地区：[1]广州市番禺区妇幼保健院新生儿科,广东广州511400

出　　处：《中国医药科学》2022年第10期84-87,共4页China Medicine And Pharmacy

摘　　要：目的探讨采用气管插管-注入外源性肺泡表面活性剂(PS)-拔管-经鼻持续气道正压通气技术(INSURE技术)与经微管气管内注入PS技术(LISA技术)分别应用于早产儿呼吸窘迫综合征(NRDS)的治疗效果。方法选取广州市番禺区妇幼保健院新生儿科于2020年1月至2021年8月收治NRDS早产儿73例,随机分为对照组(INSURE技术,n=38)和观察组(LISA技术,n=35),对两组患儿给药前后血气指标变化及治疗过程中主要观察指标(脉搏SpO_(2)下降、心动过缓、再次应用PS及72 h内再次机械通气)等数据进行统计学分析,并评价其治疗效果。结果治疗后,观察组和对照组总有效率均较高,两者比较差异无统计学意义(P>0.05);观察组血气指标[酸碱度(pH)、氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))及氧合指数(PaO_(2)/FiO_(2))]均高于对照组,治疗相关指标(心动过缓、脉搏SpO_(2)下降及72 h内再次机械通气)发生率低于对照组,差异有统计学意义(P<0.05)。结论NRDS患儿应用LISA技术治疗效果显著优于INSURE技术。Objective To investigate the therapeutic efficacy of tracheal intubation-injection of exogenous pulmonary surfactant(PS)–extubation-nasal continuous positive airway pressure ventilation(intubationsurfactant-extubation,INSURE technology)and intratracheal injection of PS through microtubule(less invasive surfactant administration,LISA technology)in the treatment of neonatal respiratory distress syndrome(NRDS).Methods A total of 73 cases of NRDS premature infants admitted to and treated in the Department of Neonatology of Panyu Maternal and Child Health Hospital in Guangzhou City from January 2020 to August 2021 were selected,and they were randomly divided into the control group(with INSURE technology,n=38)and the observation group(with LISA technology,n=35).Statistical analysis was performed on the blood gas index changes before and after drug administration and the data of main observation indices during the treatment process(pulse SpO_(2) decline,bradycardia,PS reuse and mechanical ventilation within 72 h)and other data in the two groups of children,and the therapeutic efficacy was evaluated.Results After treatment,the overall response rates of the observation group and the control group were both relatively high,without statistically significant contrast difference between them(P>0.05).The values of blood gas indices(pH,partial pressure of oxygen,partial pressure of carbon dioxide and oxygenation index)in the observation group were higher than those in the control group,and the incidence rates of treatment-related indices(bradycardia,decreased pulse SpO_(2) and re-mechanical ventilation within 72 h)were lower than those in the control group,with statistically significant differences(P<0.05).Conclusion The therapeutic effect of LISA technology in children with NRDS is significantly better than that of INSURE technology.

关 键 词：气管插管-注入外源性PS-拔管-经鼻持续气道正压通气技术 经微管气管内注入PS技术 早产儿呼吸窘迫综合征 疗效评价 

分 类 号：R722.6[医药卫生—儿科]