阻塞性呼吸睡眠暂停合并急性脑梗死患者神经恢复情况及相关影响因素分析  

Analysis of Nerve Recovery and Related Factors in Obstructive Sleep Apnea Patients with Acute Cerebral Infarction

作　　者：刘慈花 黄焕容 LIU Cihua;HUANG Huanrong(Peng Pai Memorial Hospital in Haifeng County,Haifeng 516400,China)

机构地区：[1]海丰县彭湃纪念医院,海丰516400

出　　处：《世界睡眠医学杂志》2022年第3期545-547,550,共4页World Journal of Sleep Medicine

摘　　要：目的:探讨阻塞性呼吸睡眠暂停(OSA)合并急性脑梗死患者神经恢复情况及相关影响因素。方法:选取2020年1月至2020年12月海丰县彭湃纪念医院收治的急性脑梗死患者62例作为研究对象,按照多导睡眠仪监测结果分为OSA组(n=38)和非OSA组(n=24)。同时,利用美国国立卫生研究院卒中量表(NIHSS)和改良Rankin量表(mRS),评估OSA对患者神经功能恢复的影响及相关影响因素。结果:所选取的急性脑梗死患者中,61.29%发生OSA,且OSA患者NIHSS、mRS评分明显高于非OSA患者。2组出院时简易智力筛查量表(MMSE)、词语流畅性测验(VFT)评分均提升,入院时、出院时非OSA组的评分均高于OSA组,差异有统计学意义(P<0.05)。Logistic多因素回归分析表明,睡眠呼吸暂停低通气指数(AHI)、血脂血糖水平异常、心房颤动、吸烟、脑梗死部位及OSA,是脑梗死合并OSA神经功能障碍的独立危险因素。结论:急性脑梗死患者OSA发病概率较高,且急性脑梗死合并OSA患者存在较大的神经功能恢复不良风险。Objective:To investigate the neurological recovery and related factors in patients with obstructive sleep apnea(OSA)complicated with acute cerebral infarction.Methods:A total of 62 patients with acute cerebral infarction admitted to Peng Pai Memorial Hospital in Haifeng County from January 2020 to December 2020 were selected as the research subjects,and they were divided into OSA group(n=38)and non-OSA group(n=24)according to the monitoring results of polysomnography.At the same time,the National Institute of Health Stroke Scale(NIHSS)and Modified Rankin Scale(mRS)were used to evaluate the effect of OSA on neurological recovery and related factors.Results:Among the selected patients with acute cerebral infarction,61.29%developed OSA,and the NIHSS and mRS scores of OSA patients were significantly higher than those of non-OSA patients.The scores of Mini-mental State Examination(MMSE)and Verbal Fluency Test(VFT)at discharge in both groups were improved,and the scores of non-OSA group at admission and discharge were higher than those of OSA group,the difference was statistically significant(P<0.05).Logistic multivariate regression analysis showed that sleep apnea-hypopnea index(AHI),abnormal blood lipid and blood sugar levels,atrial fibrillation,smoking,cerebral infarction site and OSA were independent risk factors for cerebral infarction complicated with OSA neurological dysfunction.Conclusion:Patients with acute cerebral infarction have a higher incidence of OSA,and patients with acute cerebral infarction combined with OSA have a greater risk of poor neurological function recovery.

关 键 词：阻塞性呼吸睡眠暂停 急性脑梗死 神经恢复 影响因素 

分 类 号：R338.63[医药卫生—人体生理学]