参芎注射液对急性非ST段抬高型心肌梗死患者外周血Th17及Treg细胞亚群的影响  

Effects of Shenxiong Injection on Th17 and Treg Cells Subsets in Peripheral Blood in Patients with Acute Non-ST-Segment Elevation Myocardial Infarction

作　　者：魏傲 李强 丁玲 谭宪 郑曦 辜琴 郭东梅 罗晓丽 WEI Ao;LI Qiang;DING Ling;TAN Xian;ZHENG Xi;GU Qin;GUO Dongmei;LUO Xiaoli(The People′s Hospital of Nanchuan,Chongqing 408400,China;Daping Hospital&Institute of Surgery Research,Army Medical University(The Third Military Medical University))

机构地区：[1]重庆市南川区人民医院,重庆408400 [2]陆军军医大学大坪医院

出　　处：《西部中医药》2022年第6期107-110,共4页Western Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81300197);重庆市南川区科技计划项目(Cx2019003)。

摘　　要：目的:观察参芎注射液对急性非ST段抬高型心肌梗死(non ST segment elevation myocardial infarction,NSTEMI)患者外周血辅助性T细胞(T helper cell 17,Th17)及调节性T细胞(regulatory T cells,Treg)细胞亚群的影响。方法:选择150例NSTEMI患者,根据随机数字表法将其分为观察组和对照组,每组75例。对照组给予常规治疗,观察组在对照组治疗基础上静脉滴注参芎注射液,疗程为2周。比较两组外周血Th17及Treg细胞亚群,相关炎性细胞因子[白细胞介素6(interleukin-6,IL-6)、白细胞介素17(interleukin-17,IL-17)、转化生长因子β(transforming growth factor-β,TGF-β)]水平,心功能情况[左室舒张末期直径(left ventricular end diastolic diameter,LVEDD)、左心室射血分数(left ventricular ejection fraction,LVEF)、舒张早期充盈峰速度与舒张晚期充盈峰速度的比值(E/A比值)]、临床疗效及不良反应发生情况。结果:与治疗前比较,两组治疗后外周血Th17细胞、Th17/Treg比值、IL-6及IL-17水平明显降低(P<0.05),其中观察组上述指标降低更明显;而Treg细胞亚群和TGF-β水平明显升高,其中观察组上述指标升高更明显(P<0.05)。观察组总有效率[90.67%(68/75)]显著高于对照组[80.00%(60/75)](P<0.05)。与对照组治疗后比较,观察组LVEDD降低更明显,LVEF升高更明显(P<0.05),而E/A比值两组比较,差异无统计学意义(P>0.05)。两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论:参芎注射液可显著改善NSTEMI患者外周血Th17和Treg细胞亚群的失衡状况,发挥抗炎作用,减轻心肌损伤,从而改善心功能。Objective:To observe the effects of Shenxiong injection on Th17 and Treg cells subsets in peripheral blood in patients suffering NSTEMI.Methods:A total of 150 patients with NSTEMI were chosen,allocated to the observa-tion group and the control group according to random number table method,with 75 cases in each group.The control group accepted conventional therapy,and the observation group intravenous dripping of Shenxiong injection based on therapy the control group accepted,the course was two weeks.To compare Th17 and Treg cells subsets in peripheral blood,the levels of the associated inflammatory cytokines[IL-6,IL-17 and TGF-β],clinical effects,cardiac function[LVEDD,LVEF and E/A ratio],and the incidence of adverse reaction between both groups.Results:Compared with these indexes before treatment,the levels of Th17 cells,Th17/Treg ratio,IL-6,IL-17 lowered notably in peripheral blood after treatment(P<0.05),among them,the decrease of the indexes above in the observa-tion group was more notable;the levels of Treg cells subsets and TGF-βwere elevated notably,among them,the increase of the above indexes in the observation group was more notable(P<0.05).Total effective rate of the observation group was[90.67%(68/75)],notably higher than this[80.00%(60/75)]of the control group(P<0.05).Compared with the control group after treating,the decrease of LVEDD was more notable while the increase of LVEF was more notable in the observation group(P<0.05),and the difference had no statistical meaning in E/A ratio(P>0.05).The difference was insignificant in the incidence of adverse reaction during therapeutic period between both groups(P>0.05).Conclusion:Shenxiong injection could notably improve the imbalance between Th17 and Treg cells subsets in peripheral blood,develop anti-inflammatory effects,give play to anti-inflammatory effects,reduce myocardial damage,therefore to improve cardiac function.

关 键 词：心肌梗死 非ST段抬高型 急性 参芎注射液 辅助性T细胞17 调节性T细胞 

分 类 号：R542.22[医药卫生—心血管疾病]