变应性鼻炎病人血浆纤维胶凝蛋白-3表达与补体C3激活的关系  

Relationship between the expression of Ficolin-3 and the activation of complement C3 in patients with allergic rhinitis

作　　者：马庆华[1] 马菲[1] 李雪娟[1] MA Qinghua;MA Fei;LI Xuejuan(Department of Otorhinolaryngology,The 7th People’s Hospital of Zhengzhou,Zhengzhou,Henan 450000,China)

机构地区：[1]郑州市第七人民医院耳鼻咽喉科,河南郑州450000

出　　处：《安徽医药》2022年第7期1329-1332,共4页Anhui Medical and Pharmaceutical Journal

基　　金：河南省医学科技攻关项目(162102410022)。

摘　　要：目的 探讨变应性鼻炎病人血浆纤维胶凝蛋白-3(Ficolin-3)表达与补体C3激活的关系。方法 选取郑州市第七人民医院2017年12月至2019年12月收治的300例变应性鼻炎病人为观察组,另外选取100例无过敏史的同期健康体检者作为对照组,采用酶联免疫吸附法(ELISA)检测血浆Ficolin-3水平,采用免疫散射比浊法检测血清C3水平,采用视觉模拟量表(VAS)评分评估变应性鼻炎病人严重程度。比较两组一般资料及Ficolin-3、C3水平差异;采用Spearman分析变应性鼻炎病人Ficolin-3、C3水平相关性,及Ficolin-3、C3水平与VAS评分相关性;采用logistic回归模型分析影响变应性鼻炎发生的因素。结果 与对照组相比,观察组家族史、吸烟史、C3水平[(1.36±0.32)g/L、(1.03±0.24)g/L]均较高(P<0.05),Ficolin-3水平[(11.72±2.24)mg/L、(15.69±2.86)mg/L]较低;Spearman相关分析显示,变应性鼻炎病人Ficolin-3与C3水平、VAS评分均呈负相关(r=-0.67,r=-0.55,均P<0.05),C3水平与VAS评分呈正相关(r=0.57,P<0.05);多因素logistic回归分析结果显示,家族史、吸烟史、C3高水平均是影响变应性鼻炎发生的危险因素(P<0.05),Ficolin-3高水平是保护因素(P<0.05)。结论 变应性鼻炎病人血浆Ficolin-3水平与补体C3激活及病情严重程度均相关,可能为变应性鼻炎的预防、评估提供临床参考依据。Objective To investigate the relationship between the expression of Ficolin-3 and the activation of complement C3 in patients with allergic rhinitis.Methods A total of 300 allergic rhinitis patients admitted to the 7th People’s Hospital of Zhengzhou from December 2017 to December 2019 were selected as the observation group,and 100 healthy subjects with no history of allergies during the same period were selected as the control group.Plasma Ficolin-3 levels were detected by enzyme-linked immunosorbent assay(ELISA),serum C3 levels were detected by immune turbidimetry,and the severity of allergic rhinitis was assessed by visual analog scale(VAS).The general data,and the differences in Ficolin-3 and C3 levels between the two groups were compared;Spearman’s test was used to analyze the correlation between the levels of Ficolin-3 and C3 in patients with allergic rhinitis and the correlation between Ficolin-3 and C3 and the VAS score.A logistic regression model was used to analyze the influencing factors in the development of allergic rhinitis.Results Compared with the control group,the family history,smoking history,and C3 level of the observation group [(1.36±0.32) g/L,(1.03±0.24) g/L]were higher(P<0.05),and Ficolin-3 levels [(11.72±2.24) mg/L,(15.69±2.86) mg/L] were lower.Spearman correlation analysis showed that allergic Ficolin-3 was negatively correlated with the C3 level and VAS score in rhinitis patients(r=-0.67,r=-0.55,All P<0.05),and the C3level was positively correlated with the VAS score(r=0.57,P<0.05).Multivariate logistic regression analysis showed that family history,smoking history and high levels of C3 were the risk factors for allergic rhinitis(P<0.05),and high levels of Ficolin-3 were protective factors(P<0.05).ConclusionThe plasma Ficolin-3 level in patients with allergic rhinitis is related to the activation of complement C3 and the severity of the disease,which may provide a clinical reference for the prevention and evaluation of allergic rhinitis.

关 键 词：鼻炎 变应性 常年性 纤维胶凝蛋白-3 补体C3 相关性 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]