绵阳地区HIV/AIDS抗病毒治疗依从性及生活质量现状调查研究  

Investigation and research on HIV/AIDS antiretroviral treatment compliance and quality of life in the Mianyang area

作　　者：张兰[1] 王洪州 邓丽娟[3] 龙波[1] 余春华 刘佳 江花琼 ZHANG Lan;WANG Hongzhou;DENG Lijuan;LONG Bo;YU Chunhua;LIU Jia;JIANG Huaqiong(Department of Infection,Sichuan Mianyang 404 Hospital,621000,China;Department of Respiratory and Critical Care,Sichuan Science City Hospital,621000,China;Department of Respiratory Medicine,Sichuan Mianyang 404 Hospital,621000,China)

机构地区：[1]四川绵阳四0四医院感染科,四川绵阳621000 [2]四川省科学城医院呼吸及危重症科,四川绵阳621000 [3]四川绵阳四0四医院呼吸内科,四川绵阳621000

出　　处：《安徽医药》2022年第7期1340-1346,共7页Anhui Medical and Pharmaceutical Journal

基　　金：四川省基层卫生事业发展研究中心项目(SWFZ19-Y-38)。

摘　　要：目的 通过调查绵阳地区艾滋病病毒感染者/艾滋病(AIDS)病人(HIV/AIDS)治疗依从性及生活质量现状,分析影响因素,为制定提高病人依从性的政策和方法提供参考。方法 选择2016年5月至2019年5月绵阳市12个县市区(园区、科学城)年龄范围为18~60岁建档并正在接受高效联合抗反转录病毒治疗(HAART)的HIV/AIDS病人,收集病人社会人口学特征及AIDS治疗依从性自我效能量表(HIV-ASES)、世界卫生组织艾滋病生存质量测量简表(WHOQOL-HIV BREF)评分,分析影响病人治疗依从性及生活质量的高危因素。结果 该研究共回收有效问卷1 600份,HIV-ASES结果显示近一个月内治疗依从率为67.19%(1 600/1 659)。对治疗依从率进行logistic多因素回归,非医学专业和未采取方法提醒用药会降低治疗依从率,且结果差异有统计学意义(P<0.05)。治疗持续时间、年龄和文化程度会影响病人的生活质量得分,且差异有统计学意义(P<0.05)。结论 非医学专业和未采取方法提醒用药史是影响HIV/AIDS病人治疗依从率的独立危险因素;治疗持续时间、年龄、文化程度是影响HIV/AIDS病人生活质量得分的高危因素;HIV/AIDS病人治疗依从率和生活质量均较低,因此加强对病人提醒、督导,提高全民文化水平,对HIV/AIDS早期发现及时治疗并坚持服药,可提高病人服药依从性和生活质量。Objective To investigate the status quo of treatment compliance and quality of life of HIV/AIDS patients in Mianyang,analyze the influencing factors,and provide a reference for formulating policies and methods to improve patient compliance.Methods From May 2016 to May 2019,HIV/AIDS patients in the age range of 18-60 years old who were registered in 12 counties(parks,science cities)in the city and were receiving high-efficiency combined antiretroviral therapy(HAART) were selected for the research object.The sociodemographic characteristics and AIDS treatment adherence self-efficacy scale(HIV-ASES) and World Health Organization quality of life in HIV infection abbreviated version(WHOQOL-HIV-BREF) score were collected to analyze the high-risk factors affecting patients’ treatment adherence and quality of life.Results A total of 1 600 valid questionnaires were recovered in this survey.The HIV-ASES results showed that the treatment compliance rate in the past month was 67.19%(1 600/1 659).Logistic multivariate regression on the treatment compliance rate showed that nonmedical majors and those who did not take the method to remind medication reduced the treatment compliance rate,and the difference was statistically significant(P < 0.05).Treatment duration,age and education level affected the patients’ quality of life scores,and the difference was statistically significant(P < 0.05).Conclusions Nonmedical majors and lack of methods to remind medication history are independent risk factors affecting the treatment compliance rate of HIV/AIDS patients.Treatment duration,age and education level are high-risk factors for affecting the quality of life of HIV/AIDS patients.The treatment compliance rate and quality of life of HIV/AIDS patients are low.Therefore,strengthening the reminder and supervision of patients,providing the cultural level of the whole population,early detection of HIV/AIDS and timely treatment and adherence to medication can improve patients’ medication compliance and quality of life.

关 键 词：获得性免疫缺陷综合征 HIV感染 抗感染药 病人依从 生活质量 调查和问卷 

分 类 号：R512.91[医药卫生—内科学]