心肌梗死病人血清半乳糖凝集素3和生长刺激表达基因2蛋白与左室重构相关性  

Correlation of serum galectin-3 and growth-stimulating gene 2 protein with left ventricular remodeling in patients with acute myocardial infarction

作　　者：王晶[1] 李培[1] 白玉芝[1] 茹静[1] 汤莉莹[1] 赵霞[1] 田甜[1] 安芸[1] WANG Jing;LI Pei;BAI Yuzhi;RU Jing;TANG Liying;ZHAO Xia;TIAN Tian;AN Yun(Integrated Department,Beijing Chaoyang Hospital,Capital Medical University,Beijing,100043,China)

机构地区：[1]首都医科大学附属北京朝阳医院综合科,北京100043

出　　处：《安徽医药》2022年第7期1415-1419,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的 探究血清半乳糖凝集素3(Gal-3)和生长刺激表达基因2蛋白(sST2)在急性心肌梗死病人中的表达情况以及与左室重构的相关性。方法 选择2019年1月至2020年11月于首都医科大学附属北京朝阳医院收治的120名急性心肌梗死(AMI)病人,包括78例ST段抬高MI(STEMI)病人和42例非ST段抬高MI(NSTEMI)病人,选择40例与病人组基线特征相似个体作为对照组。血常规检测白细胞数目和中性粒细胞数目,采用ELISA检测急性心肌梗死病人血清Gal-3和sST2,以及基质金属蛋白酶2(MMP-2)和基质金属蛋白酶9(MMP-9)表达水平,超声心动图检查左心室舒张末期容积(LVEDV),左心室收缩末期容积(LVESV),左室舒张末期直径(LVEDD)和左心室射血分数(EF)。结果 与对照组比较,AMI病人白细胞数目和中性粒细胞数目增多,血清中Gal-3、sST2、MMP-2和MMP-9水平均升高,左心室重构指标LVEDV、LVEDD和LVESV水平上升,而EF水平降低,差异有统计学意义(P<0.05);STEMI组的白细胞数目和中性粒细胞数目、Gal-3、sST2、MMP-2和MMP-9水平、LVEDV、LVEDD和LVESV水平高于NSTEMI组(P<0.05),其中STEMI组Gal-3含量为(15.65±3.12)μg/L,sST2表达水平为(11.23±2.61)μg/L,LVEDV为(119.45±20.34)mL,LVEDD为(52.64±6.98)mm,LVESV为(43.22±8.12)mL,而STEMI组Gal-3含量为(9.27±2.63)μg/L,sST2表达水平为(8.32±2.11)μg/L,LVEDV为(107.68±18.66)mL,LVEDD为(42.95±5.67)mm,LVESV为(39.75±8.52)mL;相反的是,STEMI组EF为(43.85±5.74)%,而NSTEMI组EF为(53.69±6.21)%,差异有统计学意义(P<0.05)。Pearson相关系数分析,AMI病人血清中Gal-3表达水平和左心室重构指标LVEDV、LVEDD和LVESV水平呈现正相关(r=0.62,0.58,0.59);sST2表达水平和左心室重构指标LVEDV、LVEDD和LVESV水平呈现正相关(r=0.69,0.65,0.63);而EF水平和血清Gal-3、sST2表达水平呈现负相关(r=-0.57,-0.60)。结论 血清Gal-3和sST2升高与心肌梗死左室重构密切相关。Objective To investigate the expression of serum galectin-3(Gal-3) and growth stimulating gene 2 protein(sST2) in patients with acute myocardial infarction(AMI) and their correlation with left ventricular remodeling.Methods with AMI,including 78 patients with ST-segment elevation MI(STEMI) and 42 patients with non-ST-segment elevation MI(NSTEMI),were selected from January 2019 to November 2020 in the Beijing West Campus of Beijing Chaoyang Hospital,and 40 individuals with baseline characteristics similar to those of patient group were selected as the control group.The blood counts of leukocytes and neutrophils were measured routinely,and the serum levels of Gal-3,sST2,matrix metalloproteinase 2(MMP-2) and MMP-9 in patients with AMI were measured by enzyme-linked immunosorbent assay(ELISA).Left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular end-diastolic diameter(LVEDD),and left ventricular ejection fraction(EF) were examined by echocardiography.Results creased,the levels of Gal-3,sST2,MMP-2 and MMP-9 in serum increased,and the levels of the left ventricular remodeling indexes LVEDV,LVEDD and LVESV increased,while the EF level decreased,and the difference was statistically significant(P < 0.05).The number of leukocytes and neutrophils,Gal-3,sST2,MMP-2 and MMP-9 levels,LVEDV,LVEDD and LVESV in the STEMI group were higher than those in the NSTEMI group(P < 0.05).The content of Gal-3 in the STEMI group was(15.65±3.12)μg/L,the expression level of sST2 was(11.23±2.61)μg/L,the LVEDV was(119.45±20.34)mL,the LVEDD was(52.64±6.98)mm,and the LVESV was(43.22±8.12) mL,while the content of Gal-3 in the NSTEMI group was(9.27±2.63)μg/L,the expression level of sST2 was(8.32±2.11)μg/L,the LVEDV was(107.68±18.66)mL,the LVEDD was(42.95±5.67)mm,and the LVESV was(39.75±8.52)mL.In contrast,the EF in the STEMI group was(43.85±5.74)%,while the EF in the NSTEMI group was(53.69±6.21)%,and the difference was statistically significant(P<0.05).Pearson correlation coefficien

关 键 词：心肌梗死 半乳糖凝集素3 生长调节素类 超声心动描记术 多普勒 彩色 基质金属蛋白酶类 每搏输出量 左室重构 

分 类 号：R542.22[医药卫生—心血管疾病]