多黏菌素B多途径给药联合替加环素治疗1例泛耐药鲍曼不动杆菌肺部感染的疗效分析  

Analyze the efficacy of polycolistin B multiroute administration combined with tegacycline in the treatment of one patient of pulmonary infection with extensively drug resistant acinetobacter baumannii

作　　者：张小飞 郭晓红 张莉翎 朱永红[3] ZHANG Xiaofei;GUO Xiaohong;ZHANG Liling;ZHU Yonghong(Pharmacy Department,The Third peoples Hospital of Liupanshui,Liupanshui,Guizhou 553000,China;Infectious Disease,The Third peoples Hospital of Liupanshui,Liupanshui,Guizhou 553000,China;Department of Pharmacy,Affiliated Hospital of Nantong University,Nantong,Jiangsu 226001,China)

机构地区：[1]六盘水市第三人民医院药剂科,贵州六盘水553000 [2]六盘水市第三人民医院感染科,贵州六盘水553000 [3]南通大学附属医院药学部,江苏南通226001

出　　处：《安徽医药》2022年第7期1466-1469,共4页Anhui Medical and Pharmaceutical Journal

基　　金：南通市卫生健康委员会科研课题专项(YAOZ201908);南通市市级科技计划(指导性)项目(JCZ20070);江苏省药学会-奥赛康医院药学科研项目(A2021069)。

摘　　要：目的 探讨泛耐药鲍曼不动杆菌肺部感染病人抗感染治疗的有效性和安全性。方法 回顾性分析南通大学附属医院2018年2—3月收治的1例泛耐药鲍曼不动杆菌肺部感染病人的治疗过程,结合病人临床症状和相关检查进行有效性和安全性评价。结果 多黏菌素B(静脉滴注+雾化吸入)联合替加环素治疗10 d后,病人临床症状好转;替加环素用药8 d后,病人门冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)分别高于正常值5.73倍和3.85倍。结论 多黏菌素B多途径给药模式联合替加环素对泛耐药鲍曼不动杆菌肺部感染具有良好的抗菌效果;其安全性有待进一步评价。Objective To investigate the efficacy and safety of anti-infective therapy in patients of pulmonary infection with extensively drug resistant Acinetobacter baumannii.Methods The treatment process of a patient who were admitted to the Affiliated Hospital of Nantong University from February to March 2018 of pulmonary infection with pan-resistant A.baumannii were retrospectively analyzed,and the efficacy and safety were evaluated in combination with patient’s clinical symptoms and related examinations.Results Ten days after treatment with polycolistin B(intravenous + aerosolized) and tigacycline,the patient’s clinical symptoms was improved.Eight days after treatment with tigacycline,patient’s AST and ALT were 5.73 and 3.85 times higher than normal values,respectively.Conclusions It has a good antibacterial effect on pulmonary infection of pan-drug resistantce A.baumannii with Multiroute administration of polycolistin B combined with tegacycline,and its safety needs further evaluation.

关 键 词：肺炎 细菌性 鲍曼不动杆菌 抗药性 多种 细菌 多黏菌素B 替加环素 投药途径 

分 类 号：R563.1[医药卫生—呼吸系统]