基于能量代谢重编程论“阴火”与中医肿瘤发生学  

On Yin Fire and Tumor Genesis in Traditional Chinese Medicine on the Basis of Energy Metabolism Reprogramming

作　　者：黄文博 潘丽 黄娅 蒋义芳 严然[1] 祝捷[2] 由凤鸣[1,2] HUANG Wenbo;PAN Li;HUANG Ya;JIANG Yifang;YAN Ran;ZHU Jie;YOU Fengming(Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu,610075;Cancer Research Institute,Chengdu University of Traditional Chinese Medicine)

机构地区：[1]成都中医药大学附属医院,四川省成都市610075 [2]成都中医药大学肿瘤研究所

出　　处：《中医杂志》2022年第10期905-909,共5页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(82074315);四川省中医药重点学科建设项目(2100601)。

摘　　要：能量与代谢之间的相互作用可以被看作调节机体稳态的核心机制。能量代谢重编程作为肿瘤重要的生物学特性,重新定义了能量与物质在代谢网络中的通量,为肿瘤的发生发展提供能量及物质。中医阴火学说从整体角度出发构建了气火失调的病理模型,也是对能量和代谢相互作用失稳状态变化的深刻概括。基于两者为能量与代谢调节机制失稳在不同层面上的表现,认为阴火为肿瘤发生创造条件,为肿瘤生长提供动力,为肿瘤转移营造环境。而补中升阳散火法可逆转能量代谢重编程从而达到干预肿瘤的目的。The interaction between energy and metabolism can be regarded as the core mechanism for regulating body homeostasis.As an important biological characteristic of tumors,energy metabolic reprogramming redefines the flux of energy and substances in the metabolic network,and provides energy and substances for the occurrence and development of tumors.Based on the theory of yin fire in traditional Chinese medicine,a pathological model of energy and fire disorder is built from a holistic perspective,which profoundly summarizes the instability changes of the interaction between energy and metabolism.Based on the performance of both energy and fire in the energy and metabolic regulation mechanisms at different levels,it is believed that yin fire creates conditions for the occurrence,development and metastasis of tumors.Therefore,the method of supplementing the center,raising yang,and reducing fire is recommended to revise the reprogramming of energy metabolism,and thereby providing new ideas for the clinical treatment of tumors.

关 键 词：阴火 能量代谢重编程 中医肿瘤发生学 

分 类 号：R273[医药卫生—中西医结合]