基于偏振敏感光学相干层析术的口腔鳞状细胞癌组织成像  

Polarization-Sensitive Optical Coherence Tomography for Oral Squamous Cell Carcinoma Tissue Imaging

作　　者：胡慕芸 杨迪 杨子晗 尚建伟[2] 张军[3] 梁艳梅[1] Hu Muyun;Yang Di;Yang Zihan;Shang Jianwei;Zhang Jun;Liang Yanmei(Institute of Modern Optics,Nankai University,Tianjin Key Laboratorif of Micro-Scale Optical Information Science and Teclmology,Tianjin 300350,China;Department of Oral Medicine,Tianjin Stomatological Hospital,Department of Oral Medicine,Hospital of Stomatology,Nankai University,Tianjin 300041,China;Department of Oral-Maxillofacial Suvgery,Tianjin Stomatological Hospital,Department of Oral-Maxillofacial Surgery,Hospital of Stomatology,Nankai University,Tianjin 300041,Chuia)

机构地区：[1]南开大学现代光学研究所,天津市微尺度光学信息技术科学重点实验室,天津300350 [2]天津市口腔医院病理科,南开大学附属口腔医院病理科,天津300041 [3]天津市口腔医院口腔颌面外科,南开大学附属口腔医院口腔颌面外科,天津300041

出　　处：《光学学报》2022年第10期175-182,共8页Acta Optica Sinica

基　　金：国家自然科学基金(61875092);京津冀基础研究合作专项项目(19JCZDJC65300);天津市科技支撑重点项目(17YFZCSY00740)。

摘　　要：口腔鳞状细胞癌(OSCC)发病率较高且预后效果有限,早期诊断和术中准确识别病变边界对于改善预后效果具有重要意义。偏振敏感光学相干层析术(PS-OCT)在获得组织微观结构信息的同时,可以获得组织的偏振信息,提高组织诊断的特异性。为验证PS-OCT技术在OSCC诊断应用中的可行性,利用自行开发的高分辨率PS-OCT系统对离体的OSCC组织进行了成像。初步的成像结果表明,与正常组织相比,OSCC具有明显的双折射特性,利用累积相位延迟可以明显地区分正常组织和癌组织。最终证明,高分辨率的PS-OCT技术在OSCC组织的识别诊断和边界检测方面具有很大的潜力,可以辅助医生进行疾病的筛查和术中边界检测。Oral squamous cell carcinoma(OSCC)has a high incidence and limited prognosis,and it is of great significance to improve the prognosis by early diagnosis and accurate identification of the lesion boundaries during surgery.Polarization-sensitive optical coherence tomography(PS-OCT)can not only obtain tissue microstructure information,but also obtain tissue polarization information,which can improve the specificity of tissue diagnosis.In order to verify the feasibility of PS-OCT technology in the diagnosis of OSCC,a self-developed high-resolution PS-OCT system is used to image OSCC tissue ex vivo.The preliminary imaging results show that OSCC has an obvious birefringence effect compared with the normal tissue,and the accumulative phase retardation can be used to distinguish normal tissues and cancerous tissues.Finally,it is proved that high-resolution PS-OCT technology has great potential for identification,diagnosis,and boundary detection of OSCC tissue.In addition,it can assist surgeons in disease screening and intraoperative boundary detection.

关 键 词：医用光学 光学相干层析术 偏振 口腔 鳞状细胞癌 

分 类 号：TN247[电子电信—物理电子学]