自拟养阴益气祛邪汤结合火针及刺络放血治疗玫瑰痤疮肺胃热盛证临床研究  

Clinical study on self-made Yangyin Yiqi Quxie Decoction combined with fire-needle pricking collaterals and bloodletting for the rosacea patients with excessive heat of lung and stomach

作　　者：马莉 黄咏梅 王萍 Ma Li;Huang Yongmei;Wang Ping(Department of Skin,Xining First People's Hospital,Xining 810000,China)

机构地区：[1]西宁市第一人民医院皮肤科,西宁810000

出　　处：《国际中医中药杂志》2022年第5期521-525,共5页International Journal of Traditional Chinese Medicine

基　　金：西宁市科技计划项目(2020-M-35)。

摘　　要：目的评价自拟养阴益气祛邪汤结合火针及刺络放血治疗玫瑰痤疮肺胃热盛证临床疗效。方法将符合入选标准的2018年2月-2021年2月本院120例玫瑰痤疮肺胃热盛证患者采用双色球法随机分为2组,每组60例。对照组给予西医常规疗法、火针及刺血疗法治疗,研究组在对照组基础上服用自拟养阴益气祛邪汤,2组均治疗6周。分别于治疗前后进行临床症状评分,采用化学发光法检测血清IL-6、IL-17、IL-37水平,记录治疗期间的不良反应,评价临床疗效。结果研究组总有效率为90.0%(54/60)、对照组为70.0%(42/60),2组比较差异有统计学意义(χ^(2)=7.50,P=0.006)。研究组治疗后,血清IL-6、IL-17、IL-37水平低于对照组(t值分别为30.94、9.73、14.84,P值均<0.001);灼热、丘疹脓疱、瘙痒、干燥、红斑、毛细血管扩张评分及总分低于对照组(t值分别为5.68、14.69、10.35、15.83、13.44、14.37、23.13,P值均<0.001)。2组治疗期间未见明显不良反应。结论自拟养阴益气祛邪汤结合火针及刺络放血可缓解玫瑰痤疮肺胃热盛证患者的临床症状,降低血清炎性细胞因子水平,提高临床疗效。Objective To evaluate the clinical efficacy of self-made Yangyin Yiqi Quxie Decoction combined with fire-needle pricking collaterals and bloodletting in the treatment of rosacea with excessive heat of lung and stomach syndrome.Methods From February 2018 to February 2021,120 patients with rosacea excessive heat of lung and stomach syndrome in our hospital who met the inclusion criteria were randomly divided into 2 groups by the two-color ball method,with 60 in each group.The control group was given conventional western medicine,fire-needle pricking collaterals and bloodletting therapy,while the study group was given self-made Yangyin Yiqi Quxie Decoction on the basis of the control group.Both groups were treated for 6 weeks.The clinical symptoms were scored before and after treatment,the levels of serum IL-6,IL-17 and IL-37 were detected by chemiluminescence method,the adverse reactions during treatment were recorded and the clinical efficacy was evaluated.Results The total effective rate was 90.0%(54/60)in the study group and 70.0%(42/60)in the control group,and there was significant difference between the two groups(χ^(2)=7.50,P=0.006).After treatment,the levels of serum IL-6,IL-17 and IL-37 in the study group were significantly lower than those in the control group(t values were 30.94,9.73 and 14.84,respectively,all Ps<0.001),the scores of burning,pustules,pruritus,dryness,erythema,telangiectasia and the total scores in the study group were significantly lower than those in the control group(t values were 5.68,14.69,10.35,15.83,13.44,14.37 and 23.13,respectively,all Ps<0.001).There were no obvious adverse reactions in both groups during treatment.Conclusion The self-made Yangyin Yiqi Quxie Decoction combined with fire-needle pricking collaterals and bloodletting can relieve the symptoms in patients with rosacea excessive heat of lung and stomach syndrome,reduce serum inflammatory cytokine levels,and improve clinical effects.

关 键 词：痤疮样疹 酒渣鼻 肺胃热盛证 自拟养阴益气祛邪汤 火针疗法 放血疗法(中医) 

分 类 号：R275.9[医药卫生—中西医结合]