补肾活血中药治疗膝骨关节炎作用机制研究进展  

Research progress on the mechanism of tonifying kidney and activating blood Chinese medicine for knee osteoarthritis

作　　者：李远栋[1] 王平[1] 张君涛[1] 张超[1] 卜寒梅 刘爱峰[1] Li Yuandong;Wang Ping;Zhang Juntao;Zhang Chao;Bu Hanmei;Liu Aifeng(Orthopedics and Traumatology,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China)

机构地区：[1]天津中医药大学第一附属医院骨伤科国家中医针灸临床医学研究中心,天津300381

出　　处：《国际中医中药杂志》2022年第5期595-598,共4页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81873316、81102607、81673994、51573137);天津市教委科研计划(2019KJ064);王平劳模创新工作室-天津市教委资助项目(津教工〔2016〕3号);中医传承工作室-天津卫计委资助项目(津卫中〔2017〕193号)。

摘　　要：膝骨关节炎的重要病机在于肾虚血瘀,临床多采用补肾活血中药治疗,可取得较好疗效。现有文献主要针对补肾活血单味药,以及中药复方,如包含补肾活血中药的经典方右归丸、独活寄生汤,或基于补肾活血思路自拟的经验方补肾活血方、补肾通络方等开展研究。补肾活血中药主要通过调控氧化应激反应、调节炎性细胞因子水平、调节NO水平、调控淋巴功能微循环、抑制软骨细胞凋亡、调节软骨代谢、保护及修复软骨、抑制基质降解酶来发挥治疗作用。The important pathogenesis of knee osteoarthritis(KOA)lies in kidney deficiency and blood stasis.Therefore,Traditional Chinese Medicine(TCM)for tonifying the kidney and activating blood circulation is widely used in clinical practise with high response.The existing literature mainly focuses on single medicine for tonifying the kidney and activating blood circulation,as well as TCM compounds,such as classic prescriptions Yougui Pill,Duhuo Jisheng Decoction,which contain TCMs for tonifying the kidney and activating blood circulation,or self-made empirical prescriptions Bushen Huoxue Recipe and Bushen Tongluo Recipe,which are based on the idea of tonifying the kidney and activating blood circulation.The above TCMs mainly regulate oxidative stress response,inflammatory cytokine level,no level,lymphatic function and microcirculation Inhibit chondrocyte apoptosis,regulate cartilage metabolism,protect and repair cartilage,and inhibit matrix degrading enzymes to play a therapeutic role.

关 键 词：骨关节炎 膝 补肾活血 中药 作用机制 综述 

分 类 号：R274.9[医药卫生—中西医结合]