组织工程气管软骨再生的新策略  

New strategies for cartilage regeneration in tissue-engineered trachea

作　　者：卢毅 孙飞 王志豪 史宏灿 Lu Yi;Sun Fei;Wang Zhihao;Shi Hongcan(Jiangsu Key Ixiboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases,Institute of Translational Medicine,Medical College,Yangzhou University,Clinical Medical Collegey Yangzhou University,Yangzhou 225000,China)

机构地区：[1]扬州大学临床医学院,扬州大学医学院(转化医学研究院),江苏省中西医结合老年病防治重点实验室,扬州225000

出　　处：《国际外科学杂志》2022年第4期273-278,共6页International Journal of Surgery

基　　金：国家自然科学基金面上项目(81770018, 82070020)。

摘　　要：气管外伤、狭窄、肿瘤以及部分先天性疾病可严重损伤正常通气功能,引起组织缺氧,危及患者的生命。气管病变切除重建是治疗这些疾病最为有效的方法。目前在临床中仍无长期安全可靠的方法能够实现长段气管损伤后的重建,组织工程化气管可能是目前这种情况的解决方案。软骨作为组织工程气管结构中最重要的部分之一,起到提供力学支撑并维持气管整体性的关键作用。组织工程气管软骨再生过程中的几个重要组成部分包括软骨细胞的来源、组织工程支架的构建策略和水凝胶材料复合支架的制备、生物活性因子的研究和应用等,本文通过对这几个部分进行探讨,综述了组织工程气管软骨再生的新策略以及所存在的障碍,以期为临床提供参考。The normal ventilatory function is severely impaired by tracheal traumas,stenoses,tumors and some congenital diseases,which could result in tissue hypoxia and endangering the life of the patient.Resection and reconstruction of tracheal lesions is the most effective way to treat these diseases.At present,there is still no long-term safe and reliable method to achieve the reconstruction of long-segment trachea injury in clinical practice,and tissue-engineered trachea may be the solution to this situation.Cartilage,as one of the most important parts of tissue engineered trachea,plays a key role in providing mechanical support and maintaining the integrity of trachea.Tracheal tissue engineering cartilage regeneration process consists of several important parts,including the source of the cartilage cells,tissue engineering scaffold construction strategy and hydrogel composite scaffold material preparation,and the affecting factors of biological activity and application.This article reviews the new strategies of tissue engineered tracheal cartilage regeneration and the existing obstacles in order to provide reference for clinical practice.

关 键 词：组织工程 软骨发生 组织支架 水凝胶 种子细胞 生物活性因子 

分 类 号：R318.08[医药卫生—生物医学工程]