血液黏性对脉搏波传播特性影响的定量分析  

Quantitative analysis of the influence of blood viscosity on pulse wave propagation characteristics

作　　者：卢意成 李本森 缪馥星[1] 龚文波 LU Yicheng;Li Bensen;MIAO Fuxing;GONG Wenbo(Key laboratory of impact and safety engineering,Ningbo University,Ningbo 315211;Wanghui Workroom,Ningbo Hospital of Traditional Chinese Medicine,Ningbo 315010)

机构地区：[1]宁波大学冲击与安全工程教育部重点实验室,宁波315211 [2]宁波市中医院王晖工作室,宁波315010

出　　处：《北京生物医学工程》2022年第3期235-241,共7页Beijing Biomedical Engineering

基　　金：国家自然科学基金(11872218,11572161);浙江省中医药科技计划(2022ZB317);浙江省陈霞波名老中医专家传承工作室(GZS2017017);宁波市首批医疗卫生品牌学科基金(PPXK2018-07)资助。

摘　　要：目的通过定量分析血液黏性对脉搏波传播特性的影响,为血液黏性的无创检测研究提供一种新的思路。方法假设血管为弹性薄壁圆管、血液为均质牛顿流体,应用多物理场仿真软件COMSOL Multiphysics建立血液-血管系统的有限元模型。采用双向流固耦合方法,分别选取血液动力黏性系数0、0.002、0.004、和0.006 Pa·s计算得到压力脉搏波与轴向速度脉搏波曲线,从脉搏波峰值以及波速方面定量分析人体肱动脉中血液黏性对脉搏波传播特性的影响。结果血液黏性对脉搏波波速的影响比较微弱,不同动力黏性系数下的波速差距仅在1%左右。血液黏性对能量的耗散作用会使脉搏波的波峰值减小,初步分析可知,当血液动力黏性系数在0~0.006 Pa·s时,血液黏性越大脉搏波峰值衰减幅度越大;且黏性系数每增大0.002 Pa·s,压力脉搏波峰值衰减幅度增加约1.76%,轴向速度脉搏波峰值衰减幅度增加约1.20%,血管壁的变形程度减小约2.98%。结论研究结果可以为通过脉搏波进行血液黏性的无创检测研究提供参考依据。Objective To quantitatively analyze the effect of blood viscosity on pulse wave propagation,and to provide a new idea for non-invasive detection of blood viscosity.Methods The finite element model of the blood-vessel system was created using COMSOL Multiphysics,assuming that the blood vessels were elastic thin-walled circular tubes and the blood was a homogeneous Newtonian fluid.The blood dynamic viscosity coefficients of 0,0.002,0.004,and 0.006 Pa·s were chosen to calculate the pressure pulse wave and axial velocity pulse wave curves using the bidirectional fluid-solid coupling method.The peak value and wave velocity were used to quantify the effect of blood viscosity on the pulse wave propagation characteristics in the human humeral artery.Results Blood viscosity had little effect on pulse wave velocity,and the difference of wave velocity under different dynamic viscosity coefficients was only about 1%.Blood viscosity’s energy dissipation effect reduces the peak value of the pulse wave.According to preliminary analysis,the greater the blood viscosity,the greater the attenuation of the pulse wave peak value when the hemodynamic viscosity coefficient was in the range of 0-0.006 Pa·s.If the viscosity coefficient increases by 0.002 Pa·s,then the peak attenuation amplitude of the pressure pulse wave increases by about 1.76%,the peak attenuation amplitude of the axial velocity pulse wave increases by about 1.20%,and the deformation degree of vascular wall was reduced by about 2.98%.Conclusions The results can provide a reference for the noninvasive detection of blood viscosity by pulse wave.

关 键 词：脉搏波 脉搏波传播速度 血液黏性 流固耦合分析模型 数值模拟 

分 类 号：R318.01[医药卫生—生物医学工程]