Traditional Chinese medicine:an important broad-spectrum anti-coronavirus treatment strategy on COVID-19 background?  

作　　者：Run-Dong Chai Ya-Dong Fan Qi-Yao Li Huan-Tian Cui Hai-Zhao Liu Ying Wang Bo-Yang Gong Lu Han Shuai Zhang Yu-Hong Bian Jun Kang Yu Wang 

机构地区：[1]Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China [2]School of life Sciences,Shandong University,Qingdao 266071,China [3]School of life Sciences,Tianjin University,Tianjin 300072,China

出　　处：《Traditional Medicine Research》2022年第3期1-18,共18页TMR传统医学研究

基　　金：funded by National Key R&D Program of China(No.2021YFE0200300);National Key R&D Program of China(No.2021YFC1712900).

摘　　要：Coronaviruses exist widely in nature,can cause cross-species transmission,and pose serious threats to human and animal health.Over the past 20 years,coronaviruses have led to three major epidemics that have caused global panic,including severe acute respiratory syndrome,Middle East respiratory syndrome,and coronavirus disease-19.At present,coronavirus disease 19 not only spreads rapidly,but also mutates easily to escape host immune response,becoming more pathogenic.At present,there are no effective specific therapeutic drugs or vaccines.Drugs targeting severe acute respiratory syndrome coronavirus 2 and the host cell defense system that have been developed based on the structure and replication cycle of coronaviruses have a certain broad-spectrum antiviral effect;however,their efficacy still needs to be demonstrated in further clinical trials.Traditional Chinese medicine has an indispensable role in the ongoing response to coronavirus disease-19.Anti-virus treatment with traditional Chinese medicine has advantages such as broad-spectrum application,low toxicity and side effects,low susceptibility to drug resistance,and overall comprehensive regulation.Therefore,researches on effective components and mechanisms of action of the anti-viral effects of traditional Chinese medicine have increasingly gained attention.The present paper examines coronaviruses,specifically summarizing the genomes,replication mechanisms,and mutant strains.Afterward,the therapeutic effects and mechanisms of action of modern broad-spectrum anti-coronavirus drugs and traditional Chinese medicine are summarized.By considering the virus and the targets in the host comprehensively,in addition to the beneficial multi-target and multi-path antiviral effects of traditional Chinese medicines,this paper could guide the development of treatment strategies for broad-spectrum anti-coronavirus traditional Chinese medicines,and could facilitate the modernization and globalization of traditional Chinese medicine.

关 键 词：COVID-19 SARS-CoV-2 traditional Chinese medicine broad-spectrum antivirals 

分 类 号：R37[医药卫生—病原生物学]