Recent advances in research on natural product inhibitors of SREBPs  

作　　者：Yi-Ping Zhang Jing Jin Ping Li Hua Yang Zu-Guo Zheng 

机构地区：[1]State Key Laboratory of Natural Medicines,Department of Pharmacognosy,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 210009,China

出　　处：《Traditional Medicine Research》2022年第3期55-67,共13页TMR传统医学研究

基　　金：supported by the National Natural Science Foundation of China(81903871);Natural Science Foundation of Jiangsu Province(BK20190565);Fundamental Research Funds for the Central Universities(2632021ZD16).

摘　　要：Sterol regulatory element-binding proteins(SREBPs)are a class of cholesterol-sensitive transcription factors that play important roles in lipid metabolism.Natural product inhibitors of SREBPs have been shown to inhibit the synthesis of free fatty acids and cholesterol,promote the burning of brown fat,and relieve insulin resistance by inhibiting different links during the synthesis,cleavage,and transport of SREBPs,thereby improving obesity,diabetes,atherosclerosis,and other metabolic diseases and disorders.There are numerous Chinese herbal medicines with verified efficacy in the treatment of metabolic diseases,including Coptis chinensis Franch.and Pueraria peduncularis Grah.for diabetes,Pueraria peduncularis Grah.,Epimedium brevicornum Maxim.,and Panax ginseng C.A.Meyer for osteoporosis,and Nelumbo nucifera Gaertn.and Poria cocos(Schw.)Wolf.for obesity.Present-day research on the mechanisms underlying the activity of traditional Chinese medicine has indicated that certain chemical components of these traditional preparations can be used to treat metabolic diseases by inhibiting SREBPs.Progress in the research on natural product SREBP inhibitors is continuing apace,and the mechanisms of action of certain small molecules have become well established.In this study,we review recent progress in the research on natural small-molecule inhibitors of SREBPs,including flavonoids,saponins,triterpenoids,and alkaloids,which we hope will provide a useful reference for future research and development of drugs for the treatment of metabolic diseases.

关 键 词：sterol-regulatory element-binding protein lipid metabolism metabolic disease natural product traditional Chinese medicine 

分 类 号：O62[理学—有机化学]