TGF-β1、MMP-9、VEGF在输卵管妊娠中的表达和意义  

The Expression and Significance of TGF-β1,MMP-9,VEGF in Tubal Pregnancy

作　　者：金力荣[1] 杨麦青 徐洪波[4] 魏燕妮 JIN Li-rong;YANG Mai-qing;XU Hong-bo;WEI Yan-ni(Department of Obstetrics,Changyi People's Hospital,Changyi 261300,Shandong,China;Department of Pathology,Changyi People's Hospital,Changyi 261300,Shandong,China;Department of Pathology,Weifang People's Hospital,Weifang 261041,Shandong,China;Department of Blood Transfusion,Changyi People's Hospital,Changyi 261300,Shandong,China;Department of Health Management,Weifang Nursing Vocational College,Weifang 261041,Shandong,China)

机构地区：[1]昌邑市人民医院产科,山东昌邑261300 [2]昌邑市人民医院病理科,山东昌邑261300 [3]潍坊市人民医院病理科,山东潍坊261041 [4]昌邑市人民医院输血科,山东昌邑261300 [5]潍坊护理职业学院健康管理系,山东潍坊261041

出　　处：《医学信息》2022年第12期122-125,共4页Journal of Medical Information

摘　　要：目的 通过检测输卵管妊娠患者绒毛组织中TGF-β1、MMP-9、VEGF的表达变化,探讨其在输卵管妊娠中的临床意义。方法 选取2017年1月-2020年12月在本院确诊输卵管妊娠并行手术治疗的患者40例作为观察组,另选取同期因非意愿妊娠正常早孕要求人工流产的40例患者作为对照组。采用免疫组织化学方法检测两组绒毛组织中TGF-β1、MMP-9、VEGF蛋白的表达,分析TGF-β1、MMP-9、VEGF与临床指标的关系及TGF-β1与MMP-9、VEGF的相关性。结果 观察组TGF-β1、VEGF蛋白表达低于对照组,MMP-9蛋白表达高于对照组,差异有统计学意义(P<0.05);观察组TGF-β1、MMP-9、VEGF蛋白的表达与年龄、停经天数、孕次、体质指数均无关(P>0.05);观察组TGF-β1的表达与VEGF呈正相关(r=0.326,P<0.05),与MMP-9的表达呈负相关(r=-0.353,P<0.05)。结论 输卵管妊娠患者绒毛组织中TGF-β1、VEGF蛋白的表达减少,而MMP-9的表达增多;TGF-β1的表达与VEGF的表达呈正相关,与MMP-9的表达呈负相关;绒毛组织中TGF-β1、MMP-9、VEGF蛋白表达异常可能参与了输卵管妊娠的发生。Objective To investigate the clinical significance of TGF-β1,MMP-9 and VEGF in tubal pregnancy by detecting the expression of TGF-β1,MMP-9 and VEGF in the vill of tubal pregnancy patients.Methods Forty patients with tubal pregnancy diagnosed in our hospital from January2017 to December 2020 were selected as the observation group,and 40 patients with normal early pregnancy requiring artificial abortion during the same period were selected as the control group.Immunohistochemical method was used to detect the expression of TGF-β1,MMP-9 and VEGF protein in the villi of the two groups,and the relationship between TGF-β1,MMP-9,VEGF and clinical indicators was analyzed.Results The expression of TGF-β1 and VEGF protein in the observation group was lower than that in the control group,and the expression of MMP-9 protein was higher than that in the control group,the difference was statistically significant(P<0.05).The expression of TGF-β1,MMP-9 and VEGF protein in the observation group was not correlated with age,menopause days,pregnancy times and body mass index(P>0.05).The expression of TGF-β1 in the observation group was positively correlated with VEGF(r=0.326,P<0.05),and negatively correlated with the expression of MMP-9(r=-0.353,P<0.05).Conclusion The expression of TGF-β1 and VEGF protein in villi of patients with tubal pregnancy is decreased,while the expression of MMP-9 is increased.The expression of TGF-β1 is positively correlated with the expression of VEGF,and negatively correlated with the expression of MMP-9;abnormal expression of TGF-β1,MMP-9 and VEGF proteins in villi may be involved in the occurrence of tubal pregnancy.

关 键 词：输卵管妊娠 TGF-Β1 MMP-9 VEGF 

分 类 号：R714.22[医药卫生—妇产科学]