血清视黄醇结合蛋白与胱抑素C联合检测在糖尿病肾病诊断中的应用效果  

Application value of s erum retinol binding protein and cys tatin C combined detection in the diagnos is of diabetic nephropathy

作　　者：杨玲[1] YANG Ling(Yingcheng Center for Disease Control and Prevention,Yingcheng Hubei 432400)

机构地区：[1]应城市疾病预防控制中心,湖北应城432400

出　　处：《当代医药论丛》2022年第12期154-156,共3页

摘　　要：目的:探讨血清视黄醇结合蛋白(RBP)与胱抑素C(Cysc)联合检测在糖尿病肾病(DN)诊断中的应用价值。方法:将某医院2019年1月至2019年12月收治的50例DN患者和同期在该院接受体检的50例健康体检者作为研究对象。将50例DN患者作为研究组,将50例健康体检者作为对照组。对两组人员均进行血清RBP与Cysc联合检测。然后对比两组人员血清RBP与Cysc的水平及研究组患者中不同糖尿病(DM)病程患者血清RBP与Cysc的水平。结果:研究组患者血清RBP与Cysc的水平均高于对照组体检者,差异有统计学意义(P<0.05)。研究组患者中DM病程<6年的患者其血清RBP与Cysc的水平均低于DM病程为6~12年的患者、DM病程>12年的患者,差异有统计学意义(P<0.05)。研究组患者中DM病程为6~12年的患者其血清RBP与Cysc的水平均低于DM病程>12年的患者,差异有统计学意义(P<0.05)。结论:DN患者会出现血清RBP与Cysc水平异常升高的情况,其DM病程越长,血清RBP与Cysc的水平就越高。血清RBP与Cysc联合检测在DN诊断中的应用价值较高。Objective:To investigate the value of combined determination of serum retinol binding protein(RBP)and cystatin C(Cysc)in the diagnosis of diabetic nephropathy(DN).Methods:A total of 50 DN patients admitted to a hospital from January 2019 to December 2019 and 50 healthy subjects undergoing physical examination in the hospital during the same period were selected as the research objects.Fifty DN patients were selected as the study group and 50 healthy subjects as the control group.Serum RBP and Cysc were detected in both groups.Then,the levels of serum RBP and Cysc in the two groups and the levels of serum RBP and Cysc in patients with different stages of diabetes mellitus(DM)in the study group were compared.Results:The levels of serum RBP and Cysc in the study group were higher than those in the control group,the difference was statistically significant(P<0.05).The levels of serum RBP and Cysc in patients with DM<6 years were lower than those in patients with DM<6-12 years and patients with DM>12 years,with statistical significance(P<0.05).The levels of serum RBP and Cysc in patients with 6-12 years of DM in the study group were lower than those in patients with DM>12 years,the differences were statistically significant(P<0.05).Conclusions:Abnormal elevation of serum RBP and Cysc levels occurs in DN patients,and the longer the course of DM,the higher the levels of serum RBP and Cysc.The combined detection of serum RBP and Cysc has high application value in the diagnosis of DN.

关 键 词：视黄醇结合蛋白 胱抑素C 糖尿病肾病 

分 类 号：R446[医药卫生—诊断学]