喉三针对阻塞性睡眠呼吸暂停低通气综合征患者血清miR-233表达的影响  

Impact of Hou San Zhen on the Expression of Serum MiR-233 in Patients with Obstructive Sleep Apnea-hypopnea Syndrome

作　　者：魏妍荣[1] 岳俊楠 WEI Yanrong;YUE Junnan(Traditional Chinese Medicine Hospital of Xinjiang Medical University,Urumqi 830000,China)

机构地区：[1]新疆医科大学附属中医医院,乌鲁木齐830000

出　　处：《上海针灸杂志》2022年第6期552-556,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：新疆医科大学附属中医医院院级课题(ZYY202019)。

摘　　要：目的观察喉三针对阻塞性睡眠呼吸暂停低通气综合征患者血清miR-233表达的影响。方法将98例阻塞性睡眠呼吸暂停低通气综合征患者按照随机数字表法分为治疗组与对照组,每组49例。对照组予西医常规治疗,治疗组在对照组治疗基础上予针刺治疗。观察两组治疗前后多导睡眠监测(PSG)的变化。比较两组治疗前后血清miR-233表达水平、血清炎性因子、氧化应激指标及血管内皮功能水平。结果治疗后,两组PSG指标均较同组治疗前显著下降,且治疗组优于对照组,差异均具有统计学意义(P<0.05)。治疗后,两组血清miR-233表达水平均较同组治疗前提高,且治疗组高于对照组,差异均具有统计学意义(P<0.05)。治疗后,两组血清炎性因子指标、氧化应激指标及血管内皮功能指标均较治疗前改善,且治疗组优于对照组,差异具有统计学意义(P<0.05)。结论在西医常规治疗基础上,喉三针可有效改善阻塞性睡眠呼吸暂停低通气综合征患者的睡眠质量,其作用机制可能与提高血清miR-233表达,改善患者氧化应激状态,降低炎症反应,进而恢复血管内皮功能有关。Objective To observe the impact of Hou San Zhen(acupuncture by selecting three throat-pertinent acupoints)on the expression of serum miR-233 in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS).Method Ninety-eight OSAHS patients were divided into a treatment group and a control group using the random number table method,with 49 cases in each group.The control group was offered conventional Western medicine treatment,based on which the treatment group was given acupuncture intervention.Before and after treatment,polysomnography(PSG)was observed in the two groups.The levels of serum miR-233 level,serum inflammatory factors,oxidative stress indicators,and vascular endothelial function were compared before and after treatment.Result After treatment,the PSG parameters dropped significantly in both groups,and the treatment group was superior to the control group,showing statistical significance(P<0.05).The expression level of serum miR-233 increased after treatment in both groups and was higher in the treatment group than in the control group,all showing statistical significance(P<0.05).After treatment,the serum inflammatory factors,oxidative stress indicators,and vascular endothelial function indicators showed improvements in both groups,and the treatment group was superior to the control group,showing statistical significance(P<0.05).Conclusion Based on the conventional Western medicine treatment,Hou San Zhen can improve sleep quality in patients with OSAHS,and its mechanism of action maybe associated with the increase in the expression of serum miR-233,improvement in oxidative stress level,down-regulation of inflammatory reactions,and the subsequent recovery of vascular endothelial function.

关 键 词：针刺疗法 喉三针 阻塞性睡眠呼吸暂停低通气综合征 氧化应激 炎性因子 

分 类 号：R246.1[医药卫生—针灸推拿学]