新世纪20年:中药炮制机制研究热点与前沿分析  

Twenty years in the 21st century:research hotspots and frontier analysis on Chinese medicine processing mechanism

作　　者：杨冰 杨陆 周滨滨 杨菊 郭舒臣 封亮 贾晓斌 YANG Bing;YANG Lu;ZHOU Bin-bin;YANG Ju;GUO Shu-chen;FENG Liang;JIA Xiao-bin(School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学中药学院,江苏南京211198

出　　处：《中国中药杂志》2022年第5期1161-1169,共9页China Journal of Chinese Materia Medica

基　　金：国家重点研发计划项目(2018YFC1706900);国家自然科学基金项目(81573620);中国药科大学双一流建设创新团队项目(CPU2018GY11)。

摘　　要：中药炮制机制研究是完善中药炮制工艺、制定饮片质量标准、提升中药临床疗效、丰富中药炮制理论、推动中药炮制学科发展的关键与核心基础。新世纪20年,众多科研工作者对中药炮制机制进行了深入研究,并在炮制过程中的化学成分转化、活性成分的体内过程变化、有毒中药炮制减毒规律、加辅料炮制增效减毒机制及生物医学新技术应用等方面取得了显著进展,初步阐明了多味中药炮制机制,极大地促进了中药炮制学科发展。纵观中药炮制机制发展,发现中药炮制机制研究逐渐将化学成分的体外转化与体内吸收、转运与代谢结合,将宏观机体生物效应与微观细胞、分子、靶点、通路结合,且更加注重从整体层面探究炮制机制,并初步形成了中药炮制机制现代系统研究体系。为进一步统筹推进中药炮制科学发展,笔者提出中药炮制机制研究需密切结合中药药性、重视疾病状态对药物作用方式及效应强度的影响、顺应中医药临床复方配伍用药的特点及充分利用系统生物学整体观的思路与建议,并进一步强调从传统中医药理论及中医药临床用药特点深入剖析中药炮制机制。The research on the processing mechanism of Chinese medicine is the key and core foundation to improve processing technologies of Chinese medicine,formulate the quality standards of Chinese medicinal pieces,enhance the clinical efficacy of Chinese medicine,enrich Chinese medicine processing theories,and promote the development of Chinese medicine processing.Many researc-hers have conducted in-depth exploration on the processing mechanism of Chinese medicine in the 20 years in the 21 st century.Significant progress has been made in the transformation of chemical components during the processing,the change of active components in the body,the law of toxicity attenuation in the processing of toxic Chinese medicine,the mechanism of efficacy enhancement and toxicity attenuation of processing with auxiliary materials,and the application of new biomedical technologies.At present,the processing mechanism of multiple Chinese medicines has been preliminarily clarified,which has greatly promoted the development of Chinese me-dicine processing.The development of the processing mechanism of Chinese medicine reveals that the in vitro transformation of chemical components is combined with the in vivo absorption,transport,and metabolism,and the macroscopic biological effects of the organism are combined with the cells,molecules,targets,and pathways in the study of the processing mechanism of Chinese medicine.More attention has been paid to exploring the processing mechanism from the overall level,and a modern systematic research system on the processing mechanism of Chinese medicine has been initially formed.To further promote the scientific development of Chinese me-dicine processing,the present study proposed that the research on the processing mechanism of Chinese medicine should take Chinese medicine properties into account,focus on the influence of disease condition on the mode of action and effect strength of the drugs,comply with the characteristics of clinical compound compatibility of Chinese medicine,use the holistic v

关 键 词：炮制机制 研究热点 前沿 减毒 增效 

分 类 号：R283[医药卫生—中药学]