酒萸肉环烯醚萜类化学成分研究  

Iridoids of wine-processed Corni Fructus

作　　者：李红彬 冯庆梅 张玲霞[1,2] 王静[1,2] 池军[1,2] 王智民 代丽萍[1,2] 陈随清[1] LI Hong-bin;FENG Qing-mei;ZHANG Ling-xia;WANG Jing;CHI Jun;WANG Zhi-min;DAI Li-ping;CHEN Sui-qing(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Engineering Technology Research Center for Comprehensive Development and Utilization of Authentic Medicinal Materials in Henan Province,Henan University of Chinese Medicine,Zhengzhou 450046,China;National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]河南中医药大学药学院,河南郑州450046 [2]河南中医药大学河南省豫产道地药材综合开发利用工程技术研究中心,河南郑州450046 [3]中国中医科学院中药研究所中药质量控制技术国家工程实验室,北京100700

出　　处：《中国中药杂志》2022年第5期1273-1278,共6页China Journal of Chinese Materia Medica

基　　金：国家重点研发计划项目(2017YFC1701904-3);中央本级重大增减支项目(2060302-1904-24)。

摘　　要：综合运用各种柱色谱分离技术对酒萸肉的化学成分进行研究,并应用现代波谱技术对分离得到的化合物进行结构鉴定。从酒萸肉的水提取物中分离得到10个环烯醚萜类化合物,分别为7β-O-(2″-formylfuran-5″-methylene)-morroniside(1)、7-脱氢马钱子苷(7-dehydrologanin,2)、獐牙菜苷(sweroside,3)、7β-O-甲氧基莫诺苷(7β-O-methylmorroniside,4)、7α-O-甲氧基莫诺苷(7α-O-methymorroniside,5)、7β-O-乙氧基莫诺苷(7β-O-ethylmorroniside,6)、7α-O-乙氧基莫诺苷(7α-O-ethylmorroniside,7)、山茱萸新苷(cornuside,8)、脱水莫诺苷元(sarracenin,9)、马钱苷(loganin,10)。其中化合物1为新化合物,命名为cornushmf A。A new iridoid glycoside,cornushmf A(1)and nine known iridoids(2-10)were isolated from the water extract of the wine-processed Corni Fructus by various column chromatographies.Their chemical structures were identified by comprehensive spectroscopic methods as 7β-O-(2″-formylfuran-5″-methylene)-morroniside(1),7-dehydrologanin(2),sweroside(3),7β-O-methylmorroniside(4),7α-O-methylmorroniside(5),7β-O-ethylmorroniside(6),7α-O-ethylmorroniside(7),cornuside(8),sarracenin(9),and loganin(10).

关 键 词：酒萸肉 化学成分 环烯醚萜类 

分 类 号：R284.1[医药卫生—中药学]