慢性眼部移植物抗宿主病治疗的研究进展  

Research progress in the treatment of chronic ocular graft-versus-host disease

作　　者：柯婉仪 周敏[1] 蔡乐琪(综述) 万鹏霞(审校) KE Wanyi;ZHOU Min;CAI Leqi;WAN Pengxia(Department of Ophthalmology,First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China)

机构地区：[1]中山大学附属第一医院眼科,广州510080

出　　处：《眼科学报》2022年第5期416-423,共8页Eye Science

基　　金：国家药监局合作课题(K0601300);广东省药学会基金(2019QX16)。

摘　　要：眼部移植物抗宿主病发生在超过一半的慢性移植物抗宿主病患者中,涉及眼表持续的炎症以及纤维化改变,最常见的表现为干燥性角膜结膜炎。严重的眼部移植物抗宿主病不但影响患者的工作和生活质量,同时也增加了其他眼部并发症的风险。慢性眼部移植物抗宿主病的治疗主要包括局部应用人工泪液、血清类制剂、抗炎药物等药物治疗,佩戴隐形眼镜、睑板腺按摩等物理治疗、封闭泪点、重建眼表等手术治疗。随着对眼部移植物抗宿主病发病机制的深入研究,许多新的治疗药物和治疗手段涌现临床。总结目前慢性眼部移植物抗宿主病在药物治疗、物理治疗、手术治疗方面的最新研究进展,将有助于为慢性眼部移植物抗宿主病的治疗带来更多选择和更新的研究思路。More than half of the patients developed chronic graft-versus-host disease after accepting allogeneic hematopoietic stem cell transplantation suffer from ocular graft-versus-host disease.Ocular graft-versus-host disease involves persistent inflammation and fibrosis of the ocular surface and keratoconjunctivitis sicca is the most common symptom.Severe ocular graft-versus-host disease not only affects patients’life quality,but also increases the risk of other ocular complications.The treatment of chronic ocular graft-versus-host disease mainly includes drug treatment,such as local application of artificial tears,serum eye drops and anti-inflammatory drugs;physical treatment,such as wearing contact lenses and meibomian gland massage;surgical treatment,such as punctal occlusion and reconstructing ocular surface.With the in-depth study of the pathogenesis of ocular graft-versushost disease,many new therapeutic drugs and methods have emerged.Summarizing the latest research progress in drug,physical and surgical therapy of chronic ocular graft-versus-host disease will give us insights into treatment options and hot spot of research.

关 键 词：眼部移植物抗宿主病 干眼 眼表 治疗 环孢素 

分 类 号：R77[医药卫生—眼科]