不同脉冲超声强度对在体人皮肤中甘油渗透性和光穿透深度的影响  

Effect of Pulsed Ultrasonic Intensities on Glycerol Permeability and Light Penetration Depth in Human Skin in vivo

作　　者：邹悦 魏华江 杨洪钦[3] 谢树森[3] 巫国勇[4] Zou Yue;Wei Huajiang;Yang Hongqin;Xie Shusen;Wu Guoyong(Key Laboratory of Laser Life Science,Ministry of Education,College of Biophotonics,South China Normal University,Guangzhou 510631,Guangdong,China;Guangdong Provincial Key Laboratory of Laser Life Science,College of Biophotonics,South China Normal University,Guangzhou 510631,Guangdong,China;Key Laboratory of Optoelectronic Science and Technology for Medicine,Ministry of Education,Fujian Normal University,Fuzhou 350007,Fujian,China;Department of Surgery,the First Affiliated Hospital,Sun Yat-Sen University,Guangzhou 510080,Guangdong,China)

机构地区：[1]华南师范大学生物光子学研究院教育部激光生命科学重点实验室,广东广州510631 [2]华南师范大学生物光子学研究院广东省激光生命科学重点实验室,广东广州510631 [3]福建师范大学医学光电科学与技术教育部重点实验室,福建福州350007 [4]中山大学附属第一医院心胸外科,广东广州510080

出　　处：《激光与光电子学进展》2022年第10期358-366,共9页Laser & Optoelectronics Progress

基　　金：国家自然科学基金(60778047);广州科技计划(201607010371)。

摘　　要：研究脉冲超声强度为0~0.8 W/cm^(2)时的不同强度超声对在体的人皮肤中甘油溶液的渗透性和光穿透深度的影响。实验采用光学相干断层扫描(OCT)成像技术做定量连续的测量。研究结果表明,脉冲超声强度为0~0.8 W/cm^(2)时,超声具有加速甘油溶液渗透、增强光穿透皮肤的能力,且皮肤的光透明效果随超声强度的增加而增大。以仅施加甘油溶液的样品为对照组,而施加超声作用及甘油溶液的样品为实验组。实验组和对照组的比较结果表明,在分别经超声强度为0.2,0.4,0.6,0.8 W/cm^(2)的超声处理的人体皮肤中,15%甘油的平均渗透系数与仅施加15%甘油处理的人体皮肤相比分别增加了2.6%,9.5%,14.7%,19.8%。脉冲超声处理的30%甘油在人体皮肤中的渗透系数分别高于仅施加30%甘油处理的对照组3.7%,12%,16.7%,22.2%。结论表明,应用强度为0.2~0.8 W/cm^(2)的超声,甘油的平均渗透系数随超声强度的增加而增加。The effect of different ultrasound intensities from 0 to 0. 8 W/cm^(2) on the permeability and light penetration depth of glycerol solutions in human skin in vivo were investigated. The experiment used optical coherence tomography(OCT) imaging technology to perform quantitative continuous measurements. The results show that ultrasound has the ability to accelerate the penetration of glycerol solution and enhance the penetration of light through the skin with the intensity of pulsed ultrasound ranging from 0 to 0. 8 W/cm^(2), and the optical clearing effect of the skin increases with an increase in ultrasound intensity. The sample that was only applied with glycerol solution was defined as the control group, and the sample with the ultrasound effect and glycerol solution applications was defined as the experimental group. When the results of experimental and control groups were compared, it was observed that the average permeability coefficient of 15% glycerol solution in human skin treated with 0. 2, 0. 4, 0. 6, 0. 8 W/cm^(2) pulsed ultrasound was increased by 2. 6%, 9. 5%, 14. 7%, and 19. 8%, respectively, compared to the samples with only 15%glycerol solution application. The average permeability coefficient of 30% glycerol solution treated with pulsed ultrasound in human skin was increased by 3. 7%, 12%, 16. 7%, and 22. 2% respectively, compared to the control group that only used 30% glycerol solution. The conclusions suggested that the average permeability coefficient of glycerol solution increased with increasing pulsed ultrasonic intensity in the range of 0. 2-0. 8 W/cm^(2).

关 键 词：生物技术 在体皮肤 生物组织光透明 光相干断层成像术 渗透系数 1/e光穿透深度 

分 类 号：R318.51[医药卫生—生物医学工程]