基于人体吸入和呼出烟气气溶胶粒径分布的气溶胶呼吸道沉降研究  

Respiratory tract deposition of aerosol based on particle size distribution from inhaled and exhaled tobacco smoke

作　　者：崔华鹏[1] 李雅雯 陈黎[1] 樊美娟[1] 刘绍锋[1] 谢复炜[1] 罗诚浩[2] 黄龙[2] 陈义坤[2] CUI Huapeng;LI Yawen;CHEN Li;FAN Meijuan;LIU Shaofeng;XIE Fuwei;LUO Chenghao;HUANG Long;CHEN Yikun(Zhengzhou Tobacco Research Institute of CNTC,Zhengzhou 450001,China;Technology Center of China Tobacco Hubei Industrial Co.,Ltd.,Wuhan 430040,China)

机构地区：[1]中国烟草总公司郑州烟草研究院,郑州高新技术产业开发区450001 [2]湖北中烟工业有限责任公司技术中心,武汉市东西湖区430040

出　　处：《烟草科技》2022年第6期58-62,共5页Tobacco Science & Technology

基　　金：国家烟草专卖局科技重大专项项目“基于气溶胶动态分布的加热卷烟气溶胶形成机理研究”[110202101074(XX-19)];国家自然科学基金项目“基于直接电离质谱的人体实际烟气有机物暴露评价的新方法研究”(21705164)。

摘　　要：为了考察烟气气溶胶在人体呼吸道的沉降特征,采用吸烟循环模拟机-快速粒径谱仪(SCS-DMS),基于志愿者实际抽吸曲线,对人体抽吸卷烟、加热卷烟和电子烟的吸入和呼出烟气气溶胶粒径分布进行在线表征,并采用多路径粒子剂量模型(MPPD),模拟研究了3类烟草制品的烟气气溶胶在人体呼吸道的沉降情况。结果表明:①在志愿者吸入和呼出过程中,卷烟、加热卷烟和电子烟烟气气溶胶的粒径增长因子分别为1.25~1.40、1.52~2.03和1.44~2.43。②不同类型样品的烟气气溶胶在呼吸道各部位的沉降系数为卷烟<加热卷烟<电子烟。③3类样品的烟气气溶胶在人体呼吸道不同部位的沉降系数均为口腔<气管支气管<肺部。④在右下肺叶的沉降系数相对较高,在肺部的最大沉降系数出现在第19~22级气管。In order to investigate the deposition of cigarette smoke aerosol in human respiratory tract,a smoking cycle simulator(SCS)was combined with a differential mobility spectrometer(DMS)for online characterization of the particle size distribution from inhaled and exhaled aerosol.Healthy adult smokers were recruited as volunteers who smoked combustible cigarettes,heated tobacco products and e-cigarettes ad libitum.The particle size distributions were fed into a multiple path particle dosimetry model(MPPD)for modeling the aerosol deposition from 3 types of inhaled tobacco products in the human respiratory tract.The results showed that:1)The size growth factors of the aerosol during smoking were 1.25-1.40,1.52-2.03 and 1.44-2.43 for cigarettes,heated tobacco products and e-cigarettes,respectively.2)The aerosol deposition coefficients in the human respiratory tract were in the order of:cigarettes<heated tobacco products<e-cigarettes.3)The aerosol deposition coefficients from the three types of tobacco products in different parts of the respiratory tract ranked as oral cavity<trachea and bronchus<lung.4)The aerosol deposition coefficient in the right lower lung lobe was higher,and the highest deposition coefficient was occurred in the 19th-22th airway generations.

关 键 词：烟草制品 气溶胶 粒径分布 吸入烟气 呼出烟气 多路径粒子剂量模型 呼吸道沉降 

分 类 号：TS411.2[农业科学—烟草工业]