Chemical approaches towards installation of rare functional groups in bacterial surface glycans  

作　　者：QIN Chun-Jun DING Mei-Ru TIAN Guang-Zong ZOU Xiao-Peng FU Jun-Jie HU Jing YIN Jian 

机构地区：[1]Key Laboratory of Carbohydrate Chemistry and Biotechnology,Ministry of Education,School of Biotechnology,Jiangnan University,Wuxi 214122,China [2]Wuxi School of Medicine,Jiangnan University,Wuxi 214122,China

出　　处：《Chinese Journal of Natural Medicines》2022年第6期401-420,共20页中国天然药物（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.22077052,21877052,21907039,22107037);China Postdoctoral Science Foundation(2020M681487,2021M691279);the National Key R&D Program of China(2020YFA0908304);the Natural Science Foundation of Jiangsu Province(BK20180030,BK20190575);the National First-class Discipline Program of Light Industry Technology and Engineering(LITE2018-14);the 111 Project(111-2-06);the Open Project of Key Laboratory of Carbohydrate Chemistry and Biotechnology(Jiangnan University),Ministry of Education(KLCCB-KF202005).

摘　　要：Bacterial surface glycans perform a diverse and important set of biological roles,and have been widely used in the treatment of bacterial infectious diseases.The majority of bacterial surface glycans are decorated with diverse rare functional groups,including amido,acetamidino,carboxamido and pyruvate groups.These functional groups are thought to be important constituents for the biological activities of glycans.Chemical synthesis of glycans bearing these functional groups or their variants is essential for the investigation of structure-activity relationships by a medicinal chemistry approach.To date,a broad choice of synthetic methods is available for targeting the different rare functional groups in bacterial surface glycans.This article reviews the structures of naturally occurring rare functional groups in bacterial surface glycans,and the chemical methods used for installation of these groups.

关 键 词：Bacterial surface glycan Chemical synthesis Amido group Acetamidino group Carboxamido group Pyruvyl ketal 

分 类 号：R284[医药卫生—中药学]