Ascyrones A-E, type B bicyclic ployprenylated acylphloroglucinol derivatives from Hypericum ascyron  

作　　者：DENG Xin XIA Jing QIAN Meng-Yu WANG Xiu-Rong HU Bo LIU Xue-Song WU Lin 

机构地区：[1]School of Pharmacy,Anhui Medical University,Inflammation and Immune Mediated Disease Laboratory of Anhui Province,Hefei 230032,China

出　　处：《Chinese Journal of Natural Medicines》2022年第6期473-480,共8页中国天然药物（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(No.31800279).

摘　　要：Five new polycyclic polyprenylated acylphloroglucinols(1-5),ascyrones A-E,and four known compounds(6-9)were isolated from the aerial parts of Hypericum ascyron.All of the isolates containing a bicyclo[3.3.1]nonane-2,4,9-trione core and a benzoyl group,belonged to type B bicyclic polyprenylated acylphloroglucinols(BPAPs).Their structures and absolute configurations were established based on spectroscopic analyses and calculated electronic circular dichroism(ECD)data.The anti-inflammatory,neuroprotective and cytotoxicity activities of compounds 1-4 and 6-9 were evaluated.Compound 6 exhibited obvious anti-inflammatory activity in lipopolysaccharide(LPS)-induced RAW264.7 cells.Compounds 1 and 9 exhibited slight cytotoxicity against Hep3B cells.Meanwhile,compound 1 showed mild neuroprotective activity against corticosterone(CORT)-induced PC 12 cell damage at 10 μmol-L^(-1).

关 键 词：Hypericum ascyron Acylphloroglucinol Anti-inflammatory activity Neuroprotective activity 

分 类 号：R284[医药卫生—中药学]