中药金银花质量标志物预测分析研究  

Analysis and prediction of quality markers of Lonicerae Japonicae Flos

作　　者：袁悦 张林林[2,3] 刘建庭 张洪兵[2] 许浚[2,3] 张铁军[2,3] YUAN Yue;ZHANG Lin-lin;LIU Jian-ting;ZHANG Hong-bing;XU Jun;ZHANG Tie-jun(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine,Tianjin Institute of Pharmaceutical Research,Tiunjin 300301,China;State Key Laboratory of Drug Delivery Technology and Pharnyicohinetics,Tianjin Institute of Pharmaceutical Research,Tianjin 300301,China)

机构地区：[1]天津中医药大学,天津301617 [2]天津药物研究院天津市中药质量标志物重点实验室,天津300301 [3]天津药物研究院释药技术与药代动力学国家重点实验室,天津300301

出　　处：《中国中药杂志》2022年第7期1730-1738,共9页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金重点项目(81830111);天津市科技计划项目中央引导地方科技发展专项(20ZYCGSN00200)。

摘　　要：金银花是我国传统大宗药材,几千年来用于治疗炎症和各种传染病,具有确切的疗效。金银花复杂的化学成分决定其广泛的药理作用,因此评价金银花的质量仅靠几个指标成分是不够全面的。该文在质量标志物(Q-marker)的理论指导下,基于金银花化学物质组及成分传递、植物亲缘学、化学成分有效性、化学成分可测性以及化学成分特有性方面较为全面地分析与预测金银花的质量内涵,推测金银花中绿原酸、异绿原酸A、异绿原酸B、异绿原酸C、木犀草苷、芦丁、獐牙菜苷、断氧化马钱子苷可以作为金银花的候选质量标志物。Lonicerae Japonicae Flos,as common Chinese medicine,has been used for thousands of years in the treatment of inflammation and infectious diseases with definite efficacies.The complex composition of Lonicerae Japonicae Flos results in its extensive pharmacological effects,so the assessment of its quality by only a few index components is not comprehensive.Guided by the quality marker(Q-marker),the present study comprehensively analyzed and predicted the quality connotation of Lonicerae Japonicae Flos based on the chemical composition and component transfer,the phylogenetic relationship,chemical composition effectiveness,measurability,and specificity.Chlorogenic acid,isochlorogenic acids A,B,and C,luteoloside,rutin,sweroside,and secoxyloganin were predicted as candidate Q-markers of Lonicerae Japonicae Flos.

关 键 词：金银花 质量标志物 化学物质基础 药理作用 质量评价 

分 类 号：R284.1[医药卫生—中药学]