桂郁金研究进展及基于质量标志物的保肝、抗肿瘤机制分析  

Research progress of Curcuma kwangsiensis root tubers and analysis of liver protection and anti-tumor mechanisms based on Q-markers

作　　者：李泽宇 郝二伟[1,2,3,4] 杜正彩 曹瑞[1,2,3,4] 陈锋 莫柳英 吴东阳[1,2,3,4] 侯小涛 邓家刚 LI Ze-yu;HAO Er-wei;DU Zheng-cai;CAO Rui;CHEN Feng;MO Liu-ying;WU Dong-yang;HOU Xiao-tao;DENG Jia-gang(China-ASEAN Joint Laboratory for International Cooperation in Traditiorml Medicine Research,Guangxi University of Chinese Medicine,Nanning 530200,China;Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica,Nanning:530200,China;Guangxi Key Laboratory of Traditional Chinese Medicine Rheumatism Prescription Theory and Transforrjuition,Nanning 530200y China;Guangxi Scientific Research Center of Traditional Chinese Medicine,Nanning 530200,China;College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学中国-东盟传统药物研究国际合作联合实验室,广西南宁530200 [2]广西中药药效研究重点实验室,广西南宁530200 [3]广西中医湿病方药理论与转化重点实验室,广西南宁530200 [4]广西中医药科学实验中心,广西南宁530200 [5]广西中医药大学药学院,广西南宁530200

出　　处：《中国中药杂志》2022年第7期1739-1753,共15页China Journal of Chinese Materia Medica

基　　金：中国-东盟传统药物研究国际合作联合实验室建设(二期)新中心建设项目(CICAR2017-Z1);国家自然科学基金项目(82060762);广西创新驱动重大专项(桂科AA181180492);广西科技基地和人才专项(桂科AD191101553)。

摘　　要：桂郁金为广西道地药材,应用广泛,活性成分以萜类和姜黄素类为主,具有活血止痛、行气解郁、清心凉血、利胆退黄之功效。现代研究表明,其保肝、抗肿瘤、抗氧化、降血脂、免疫抑制作用显著。该文基于桂郁金的研究进展,结合质量标志物(quality marker, Q-marker)的核心概念,从植物亲缘学及化学成分特有性、传统药效药性及新的药效用途、化学成分可测性、不同加工方法、不同配伍、入血成分几个方面对桂郁金质量标志物进行预测分析,初步确定了姜黄素、莪术醇、莪术二醇、莪术烯醇、莪术二酮、吉马酮、β-榄香烯为其可能的质量标志物。同时基于质量标志物的预测结果,对其保肝、抗肿瘤特征性功效的机制进行了分析,确定了AKT1、IL6、EGFR、STAT3为其重要靶点,神经活性配体受体相互作用、氮代谢通路、癌症通路、乙型肝炎通路为其重要通路。以期为桂郁金质量评价和产品开发提供科学依据,同时拟为中药材研究提供新的研究思路和可借鉴的方法。Curcuma kwangsiensis root tuber is a widely used genuine medicinal material in Guangxi, with the main active components of terpenoids and curcumins. It has the effects of promoting blood circulation to relieve pain, moving Qi to relieve depression, clearing heart and cooling blood, promoting gallbladder function and anti-icterus. Modern research has proved its functions in liver protection, anti-tumor, anti-oxidation, blood lipid reduction and immunosuppression. Considering the research progress of C. kwangsiensis root tubers and the core concept of quality marker(Q-marker), we predicted the Q-markers of C. kwangsiensis root tubers from plant phylogeny, chemical component specificity, traditional pharmacodynamic properties, new pharmacodynamic uses, chemical component measurability, processing methods, compatibility, and components migrating to blood. Curcumin, curcumol, curcumadiol, curcumenol, curdione, germacrone, and β-elemene may be the possible Q-markers. Based on the predicted Q-markers, the mechanisms of the liver-protecting and anti-tumor activities of C. kwangsiensis root tubers were analyzed. AKT1, IL6, EGFR, and STAT3 were identified as the key targets, and neuroactive ligand-receptor interaction signaling pathway, nitrogen metabolism pathway, cancer pathway, and hepatitis B pathway were the major involved pathways. This review provides a basis for the quality evaluation and product development of C. kwangsiensis root tubers and gives insights into the research on Chinese medicinal materials.

关 键 词：桂郁金 郁金 化学成分 药理作用 质量标准 质量标志物 姜黄素 莪术醇 莪术二醇 莪术烯醇 莪术二酮 吉马酮 Β-榄香烯 

分 类 号：R285[医药卫生—中药学] R284[医药卫生—中医学]