基于中药血清药物化学的玉泉胶囊质量标志物研究  

Q-markers of Yuquan Capsules based on serum pharmacochemistry of Chinese medicine

作　　者：李太平 谭栀恩 张孟丽 欧敏 何艳梅 吴芳芳 LI Tai-ping;TAN Zhi-en;ZHANG Meng-li;OU Min;HE Yan-mei;WU Fang-fang(National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials,Guangxi Botanical Garden of Medicinal Plants,Nanning 530023,Chinu;National Chinmedomics Research Center,Heilongjiang Univensity of Chinese Medicine,Hdrbin 150040,China)

机构地区：[1]广西壮族自治区药用植物园西南濒危药材资源开发国家工程实验室,广西南宁530023 [2]黑龙江中医药大学中医方证代谢组学研究中心,黑龙江哈尔滨150040

出　　处：《中国中药杂志》2022年第7期1802-1813,共12页China Journal of Chinese Materia Medica

基　　金：中央引导地方科技发展资金专项(桂科ZY21195044);广西科技计划项目(2018JJB140057,AD18126013);广西八桂学者项目;北京市科技计划项目(Z181100001918015)。

摘　　要：该研究基于中药血清药物化学理论分析玉泉胶囊的质量标志物。应用UPLC-Q-TOF-MS和UNIFI系统分析玉泉胶囊的入血成分和代谢产物,结果共计检测到玉泉胶囊32个成分入血,包括17个原型成分,15个被代谢的成分,其中12个原型成分(人参皂苷Rh;、染料木素、芒柄花黄素、葛根素、大豆素、五味子甲素、五味子乙素、五味子丙素、五味子醇甲、五味子醇乙、戈米辛D、刺芒柄花苷)和12个被代谢的成分(人参皂苷Rg;、人参皂苷Rg;、人参皂苷Rg;、人参皂苷Ro、3′-甲氧基葛根素、大豆苷、黄芪皂苷Ⅱ、黄芪甲苷、甘草素、甘草酸、异甘草苷、毛蕊花糖苷)对糖尿病有积极的抑制作用和药理活性,这24个具有抵抗糖尿病的入血成分被认定为玉泉胶囊的质量标志物。This study analyzed the quality markers(Q-markers) of Yuquan Capsules(YQC) based on serum pharmacochemistry of Chinese medicine and detected the components and metabolites of YQC absorbed into the blood by UPLC-Q-TOF-MS and UNIFI systems. As a result, 32 components of YQC were detected, including 17 prototype components and 15 metabolized components. Among them, 12 prototype components(ginsenoside Rh;, genistein, formononetin, puerarin, daidzein, schizandrin A, schizandrin B, schizandrin C, schizandrol A, schizandrol B, gomisin D, and ononin) and 12 metabolized components(ginsenoside Rg;, ginsenoside Rg;, ginsenoside Rg;, ginsenoside Ro, 3′-methoxypuerarin, daidzin, astragaloside Ⅱ, astragaloside Ⅳ, glycyrrhizic acid, liquiritigenin, isoliquiritin, and verbascoside) showed inhibitory effects and pharmacological activities against diabetes, and these 24 blood-entering components against diabetes were identified as Q-markers of YQC.

关 键 词：玉泉胶囊 中药血清药物化学 质量标志物 UPLC-Q-TOF-MS 

分 类 号：R286.0[医药卫生—中药学]