乙型肝炎病毒标志物16246例定量检验结果分析  

Analysis of quantitative test results of hepatitis B virus markers in 16246 cases

作　　者：杨璨 张新颖 YANG Can;ZHANG Xinying(Xi'an International Medical Center Hospital,Xi'an,Shaanxi 710100,China;Xi'an Qiu Lan Hospital of Traditional Chinese Medicine,Xi'an,Shaanxi 710000,China)

机构地区：[1]西安国际医学中心医院,陕西西安710100 [2]西安秋兰中医医院,陕西西安710000

出　　处：《现代医药卫生》2022年第12期2020-2023,共4页Journal of Modern Medicine & Health

摘　　要：目的探讨某院就诊患者乙型肝炎(乙肝)五项[即乙肝病毒(HBV)表面抗原(HBsAg)、抗HBV表面抗体(HBsAb)、HBV e抗原(HBeAg)、抗HBV e抗体(HBeAb)、抗HBV核心抗体(HbcAb)]定量检测模式分布现状、特点及临床意义,以期获得HBV感染血清标志物的流行率和实现乙肝防治的科学管理。方法选取2020年10月至2021年10月在西安国际医学中心医院就诊患者16246例,采用全自动化学发光免疫分析仪CL6000i检测乙肝五项,并对检测结果进行不同模式、不同人群归类分析。结果16246例就诊患者乙肝五项检测出现17种模式,其中常见模式9种,少见模式7种,罕见模式1种。16246例就诊患者乙肝五项检测出现常见模式16128例(99.27%),少见模式114例(0.71%),罕见模式4例(0.02%)。HBsAg、HBsAb、HBeAg、HBeAb、HBcAb阳性率分别为10.92%(1774/16246)、52.83%(8582/16246)、2.45%(398/16246)、25.70%(4176/16246)、47.90%(7782/16246)。男性患者HBsAg阳性率[12.54%(1059/8442)]明显高于女性[8.78%(685/7804)],差异有统计学意义(P<0.05)。30~<40、40~<50岁患者所占比例较高,分别为11.13%、11.04%。结论建议采用乙肝定量检测结果进行人群筛查及乙肝患者的疗效观察,以实现不同人群乙肝防治的科学管理。Objective To explore the distribution status,characteristics and clinical significance of quantitative detection modes of five makers of hepatitis B[hepatitis B virus(HBV)surface antigen(HBsAg),anti-HBV surface antibody(HBsAb),anti-HBV e antigen(HBeAg),anti-HBV e antibody(HBeAb)and anti-HBV core antibody(HbcAb)]in the hospital,so as to obtain the prevalence rate of serum markers of HBV infection and realize the scientific management of prevention and treatment of hepatitis B.Methods A total of 16246 patients in this hospital from October 2020 to October 2021 were selected to be tested for the five makers of hepatitis B using a fully automated chemiluminescent immunoassay analyzer CL6000i.The test results were also categorized and analyzed by different patterns and populations.Results There were 17 patterns in the five makers of hepatitis B in 16246 patients,including nine common patterns,seven uncommon patterns and one rare pattern.In 16246 patients with hepatitis B,there were 16128 common patterns(99.27%),114 uncommon patterns(0.71%)and 4 rare patterns(0.02%).HBsAg,HBsAb,HBeAg,HBeAb,HBeAb and HBcAb positive rates were 10.92%(1774/16246),52.83%(8582/16246),2.45%(398/16246),25.70%(4176/16246)and 47.90%(7782/16246),respectively.The positive rate of HBsAg in male patients[12.54%(1059/8442)]was significantly higher than that in females[8.78%(685/7804)](P<0.05).The proportion of patients aged 30-<40 and 40-<50 years old was higher,which was 11.13% and 11.04%,respectively.Conclusion It is recommended that the results of quantitative detection of hepatitis B should be used for population screening and observation of the curative effect of patients with hepatitis B,so as to realize the scientific management of prevention and treatment of hepatitis B in different populations.

关 键 词：化学发光 免疫测定 乙型肝炎病毒 血清 生物学标记 乙型肝炎五项定量检测模式 

分 类 号：R392.7[医药卫生—免疫学] R512.62[医药卫生—基础医学]