Identification of Active Component of Hachimi-jio-gan Ameliorating Diabetic Nephropathy  

作　　者：Chan Hum Park Takashi Tanaka Takako Yokozawa 

机构地区：[1]Institute of New Frontier Research Team,Hallym Clinical and Translational Science Institute,Hallym University,Chuncheon,24252,Republic of Korea [2]Graduate School of Biomedical Sciences,Nagasaki University,Nagasaki,852-8521,Japan [3]Graduate School of Science and Engineering for Research,University of Toyama,Toyama,930-8555,Japan

出　　处：《Journal of Integrative Medicine（双语）》2022年第1期1-7,共7页中西医结合杂志（英文）

摘　　要：Conventional medicine-based Chinese herbal prescriptions,have fascinated much attention due to their extensive and unique diversity of biological effects without toxicity and/or adverse effects.Treatment with Hachimi-jio-gan(Ba-Wei-Di-Huang-Wan in Chinese)improved the dysregulated levels of hyperglycemic condition-related oxidative stress generation,advanced glycation endproduct generation,and renal function parameters.These results indicate that Hachimi-jio-gan is a prospective therapeutic agent against the pathogenesis of diabetic nephropathy.Cornel iridoid glycosides and polyphenol are the active compounds of Corni Fructus,the active component of Hachimi-jio-gan,against kidney damage caused by diabetes.Additionally,major components of the Corni Fructus,morroniside and 7-O-Galloyl-D-sedoheptulose(GS)are considered to be important contributors to prevent and/or delay the onset of kidney damage caused by diabetes.Chief of all,GS is expected to be developed as a novel therapeutic drug for the diabetes-accelerated kidney damage.

关 键 词：Diabetic nephropathy Hachimi-jio-gan Corni Fructus MORRONISIDE 7-O-Galloyl-D-sedoheptulose 

分 类 号：R69[医药卫生—泌尿科学]