2004年—2021年6月浙江省手足口病暴发疫情病原检测结果分析  

Analysis of pathogen detection results of hand-foot-mouth disease outbreak in Zhejiang Province,2004 to June 2021

作　　者：蔡剑[1] 凌锋[1] 孙继民[1] 丰燕[1] 曹艳丽[1] 缪梓萍[1] CAI Jian;LING Feng;SUN Ji-min;FENG Yan;CAO Yan-li;MIAO Zi-ping(Institute for Communicable Disease Prevention and Control,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou,Zhejiang 310051,China)

机构地区：[1]浙江省疾病预防控制中心传染病预防控制所,浙江杭州310051

出　　处：《中国卫生检验杂志》2022年第9期1061-1064,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的了解浙江省手足口病(hand-foot-mouth disease,HFMD)暴发疫情的病原检测结果,为HFMD暴发防控提供参考。方法收集浙江省2004年—2021年6月报告的HFMD暴发疫情,分析病原学种类及其流行病学特征,分析按照病原体类型和样本种类分层的检测阳性率。结果共有HFMD暴发疫情91起,主要的病原体有CA16(43.96%)、EV71(17.58%)和CA6(7.69%),平均罹患率为(8.07±5.50)%,持续时间为(15.86±9.31)d。CA6引起的HFMD暴发从首例发病到报告需要(15.70±4.87)d,EV71暴发需(10.61±8.11)d,CA16暴发需(9.31±3.97)d。共采样622份,阳性449份,总体阳性检测率为72.19%。粪便、肛拭子和咽拭子的阳性率分别为81.24%、82.55%和62.58%。EV71、CA16和CA6暴发疫情的检测阳性率分别为85.28%、81.92%和89.75%,其他肠道病毒疫情的检测阳性率为35.61%。结论CA16是浙江省近年来手足口病暴发疫情的主要病原体,建议采集粪便和肛拭子以提高检测阳性率,并加强其他肠道病毒的检测能力。Objective To understand the pathogen test results of hand-foot-mouth disease(HFMD)outbreaks in Zhejiang Province,and to provide evidence for HFMD control.Methods The hand-foot-mouth disease outbreaks reported in Zhejiang Province from 2004 to June 2021 were collected.Laboratory results and epidemiological characteristics were studied among EV71,CA16 and CA6.Positive rate of throat swab,anal swab and feces were also compared.Results A total of 91 outbreaks were detected,CA16(43.96%),EV71(17.58%),CA6(7.69%)were the main pathogens,the average attack rate of HFMD outbreaks was(8.07±5.50)%,and lasted(15.86±9.31)d.It took(15.70±4.87)d,(10.61±8.11)d,and(9.31±3.97)d from the first case’s onset to the report for CA6,EV71,CA16,respectively.A total of 449 positive samples were found among 622 samples,with positive rate of 72.19%.Positive rates were 81.24%,82.55%,and 62.58%for feces,anal swab,and throat swab.The positive rates of EV71,CA16 and CA6 outbreaks were 85.28%,81.92%and 89.75%,respectively.The positive rates of other enterovirus outbreaks were 35.61%.Conclusion CA16 was the main pathogen of hand foot mouth outbreaks in Zhejiang Province.Feces and anal swab were recommended to improve the laboratory positive rate,and detection capacity of other enterovirus should be strengthened.

关 键 词：手足口病 暴发 流行病学 病原体 检测 

分 类 号：R512.5[医药卫生—内科学]