水通道蛋白-1与腹膜透析超滤相关性的研究进展  

Research progress in the relationship between water channel aquaporin-1(AQP1)and peritoneal ultrafiltration in peritoneal dialysis

作　　者：周胜男 田娜[2] ZHOU Sheng-nan;TIAN Na(Ningxia Medical University,Yinchuan 750004,China;Department of Nephrology,General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学,银川750004 [2]宁夏医科大学总医院肾内科,银川750004

出　　处：《中国血液净化》2022年第6期449-452,共4页Chinese Journal of Blood Purification

基　　金：国家自然科学基金(81960144);宁夏自然科学基金(重点项目)(2022AAC02062)。

摘　　要：研究证实腹膜组织上有水通道蛋白-1(aquaporin 1,AQP1)表达,AQP1是腹膜超小孔的分子对应物,在腹膜跨细胞水转运中起重要作用,其结构或功能受损及在细胞内分布的改变可能导致超滤衰竭(ultrafiltration failure,UFF)的发生,是引起腹膜透析(peritoneal dialysis,PD)失败的主要原因之一,AQP1编码基因的一种常见变异与超滤(ultrafiltration,UF)减少和患者预后、技术生存率下降显著相关,证实腹膜UF功能受到遗传背景的影响。调控AQP1表达的因素包括渗透性调控、药物调控、pH调控,AQP1通道活性调控等。近年来发现,腹膜间皮细胞(peritoneal mesothelial cells,PMCs)也表达AQP1,且与UF存在相关性,在PD过程中AQP1可能具有更多重要功能,譬如AQP1对PMCs、腹膜纤维化改变具有保护作用,以AQP1作为调控靶点在改善PD超滤功能中的作用也越来越受到关注,特别在AQP1基因水平、通道活性选择性药理学调节方面。本文将对AQP1与PD超滤相关性的研究进展进行综述。Studies have confirmed that the water channel aquaporin-1(AQP1)is expressed on peritoneum.AQP1 is considered to be the molecular counterpart of the ultrasmall pore on peritoneum,and plays a fundamental role in transcellular water transport across the peritoneum.The changes of its structure,function or distribution in cells may lead to ultrafiltration failure(UFF),being one of the main causes for peritoneal dialysis(PD)failure.A common promoter variant in the gene coding AQP1 is associated with the decreased ultrafiltration(UF),patient prognosis and technology survival,indicating that genetic factors affect the efficiency of peritoneal ultrafiltration.Factors regulating AQP1 expression include permeability regulation,pharmacological regulation,pH regulation,AQP1 channel activity regulation,and others.Recent studies have found that peritoneal mesothelial cells(PMCs)also express AQP1 and are related to peritoneal ultrafiltration.AQP1 may have other functions such as protecting PMCs and the peritoneum from fibrosis.AQP1 as a regulatory target for the amelioration of ultrafiltration has been recently emphasized,especially regulating AQP1 expression at the gene level and using APQ1-selective medicines.In this review,the research progress in the relationship between AQP1 and peritoneal ultrafiltration in PD is introduced.

关 键 词：水通道蛋白1 腹膜透析 超滤 

分 类 号：R459.5[医药卫生—治疗学]