成都市复检核酸阳性新冠肺炎患者流行特征分析  

Prevalence and infectious characteristics of retest positive cases infected with SARS-CoV-2 in Chengdu city

作　　者：胡敏 岳勇 冯静[2] 涂芷菡 孟建彤 毛毅[3] 姜晓曼 庹晓莉 HU Min;YUE Yong;FENG Jing(Chengdu Workstation for Emerging Infectious Disease Control and Prevention,Chinese Academy of Medical Sciences,Chengdu,Sichuan Province 610041,China;不详)

机构地区：[1]中国医学科学院成都新发突发传染病防治工作站,四川成都610041 [2]成都市疾病预防控制中心 [3]成都市公共卫生临床医疗中心应急病区

出　　处：《中国公共卫生》2022年第6期758-761,共4页Chinese Journal of Public Health

基　　金：中国医学科学院中央级公益性科研院所基本科研业务费专项资金(2020-PT330-005)。

摘　　要：目的分析四川省成都市新型冠状病毒肺炎(新冠肺炎)复检阳性病例的流行病学及临床特征,为新冠肺炎疫情防控提供参考依据。方法截至2021年6月15日,回顾性地收集成都市147例新冠肺炎复检阳性病例资料,描述病例复检阳性前后的流行病学特征及临床特征差异。结果成都市共计有147例复检阳性病例,复检阳性170人次,复检阳性率为15.05%(147/977)。采集440份标本进行检测,不同标本类型的阳性率无明显差异(P>0.05)。复检阳性病例中,12例胸部影像学表现为进展性病变;12例有临床症状;采集180份病例住所环境样品进行检测,有2份物表涂抹样阳性,但其48名密切接触者均未发病。病例从出院至复检阳性的平均间隔为16.95 d,复检阳性病例的平均排毒期为56.58 d。复检阳性前后病例的住院时间、淋巴细胞数、D-二聚体、血清铁蛋白、肌酸激酶同工酶有明显差异(P<0.05)。结论新冠肺炎病例可出现多次复检阳性,且新冠病毒可在人体多个样本中检出,可同时采集多个标本进行检测有助于避免漏诊。Objective To analyze epidemiological and clinical characteristics of retest positive cases infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in Chengdu city,Sichuan province and to provide evidences for the prevention and control of coronavirus disease 2019(COVID-19).Methods Relevant data on 147 SARS-CoV-2 nucleic acid retest positive cases were retrospectively collected from follow-up surveys conducted 2 and 4 weeks after hospital discharge among 977 COVID-19 patients in Chengdu city as of June 15,2021.The epidemiological and clinical characteristics of the retest positive cases during hospitalization and at the retest were described.Results The retest positive rate of SARS-CoV-2nucleic acid was 15.05%and there was no significant type difference in the retest positive rate for a total of 440 various biological specimens from the cases(all P>0.05).The chest images showed progressive lesions in 12 retest positive cases and another 12 cases presented clinical symptoms of COVID-19.Among 180 surface swab specimens sampled in living environment of the retest positive cases,two were positive for SARS-CoV-2 nucleic acid test.For all the retest positive cases,the average interval from discharge to the time of retest positive was 16.95 days and the average detoxification period was56.58 days.The cases′detection results of lymphocyte count,D-dimer,serum ferritin,creatine kinase isoenzymes at the time of retest positive and duration of hospitalization were significantly different from those at the time before the retest positivity(P<0.05 for all).Conclusion Retest positive for SARS-CoV-2 nucleic acid exists and could be detected in various biological specimens among discharged COVID-19 cases.Detections of multiple specimens can facilitate the identification of the rest positive cases.

关 键 词：新型冠状病毒肺炎 复检阳性 慢性排毒 

分 类 号：R183.3[医药卫生—流行病学]