鸡MHC相关的马立克氏病遗传抗性研究进展  

Advances in MHC-related Genetic Resistance to Marek's Disease in Chickens

作　　者：金元昌 曹清国 张幽静 姜丽霞 郑传丹 陈明丽 JIN Yuanchang;CAO Qingguo;ZHANG Youjing;JIANG Lixia;ZHENG Chuandan;CHEN Mingli(Zunyi Teachers College,Zunyi Guizhou 563006,China;Comprehensive Security and Technology Promotion Center of Wuerqihan town,Yakeshi City,Yakeshi Inner Mongolia 022159,China)

机构地区：[1]遵义师范学院,贵州遵义563006 [2]内蒙古牙克石市乌尔其汉镇综合保障和技术推广中心,内蒙古牙克石022159

出　　处：《畜牧兽医科学（电子版）》2021年第22期158-159,共2页Graziery Veterinary Sciences：Electronic Version

基　　金：贵州省科技计划项目(黔科合基础-ZK[2021]一般168);遵义师范学院博士基金项目(遵师BS[2020]1号)。

摘　　要：疫苗免疫是控制马立克氏病(Marek's disease,MD)的主要手段,但由于多种原因,使免疫鸡群仍有MD暴发。而遗传抗病育种能从遗传本质上提高鸡群的抗病能力,其中基于分子标记技术的MD遗传抗病育种有望弥补疫苗接种为主的MD防控手段之不足。研究将进行BF(鸡MHCI)基因外显子7可变剪接与MD遗传抗性关系及其机制的分析,为构建BF基因可变剪外显子7为分子标记的MD遗传抗病育种的标记方法提供参考。Vaccine Immunization is the main method to control Marek's disease(MD),but for many reasons,MD outbreaks still occur in immunized chickens.Genetic Disease Resistance Breeding can improve the disease resistance of chickens genetically,and molecular marker-based disease resistance breeding is expected to make up for the shortage of vaccine-based MD control.The relationship between variable splicing of exon 7 of BF(chicken MHCI)gene and MD genetic resistance and its mechanism will be analyzed in this study,which will provide reference for constructing marker method of MD genetic resistance breeding with variable splicing exon 7 of BF gene as molecular marker.

关 键 词：鸡 马立克氏病 遗传抗性 分子标记 

分 类 号：S852.65[农业科学—基础兽医学]