类孟买血型合并妊娠1例  

Para-Bombay phenotype in a pregnant woman

作　　者：王施元 陈彬[1] 何植华 梁爽 程荣锋[4] 秦薇[1] Wang Shiyuan;Chen Bin;He Zhihua;Liang Shuang;Cheng Rongfeng;Qin Wei(Department of Obstetrics,Affiliated Shenzhen Maternity&Child Healthcare Hospital,Shenzhen 518000,China;Department of Laboratory,Affiliated Shenzhen Maternity&Child Healthcare Hospital,Shenzhen 518000,China;Shenzhen Blood Center,Shenzhen 518000,China;Medical Department,Affiliated Shenzhen Maternity&Child Healthcare Hospital,Shenzhen 518000,China)

机构地区：[1]深圳市妇幼保健院产科,深圳518000 [2]深圳市妇幼保健院检验科,深圳518000 [3]深圳市血液中心,深圳518000 [4]深圳市妇幼保健院医务科,深圳518000

出　　处：《中华围产医学杂志》2022年第5期369-372,共4页Chinese Journal of Perinatal Medicine

基　　金：深圳市妇幼保健院科研基金(FYA2018026)。

摘　　要：本文报告了1例自孕早期建册于深圳市妇幼保健院常规产前检查至孕39周自然临产分娩的类孟买血型合并妊娠产妇的临床资料。该产妇于孕12周发现血型ABO正反定型不符,ABO基因测序结果显示ABO基因型为ABO*A1.02/B.01,FUT1基因为c.551-552delAG缺失、c.880-882delTT缺失的杂合子,基因型为h1/h2。FUT2基因为357C>T,716G>A,基因型为Se/Se。孕期常规产前检查未见明显异常,于孕39周+2经阴道分娩一男婴。该新生儿ABO血型正定型为B型,无新生儿溶血病,且未见明显异常体征,1月龄随访时生长发育情况良好。类孟买血型是一种特殊的血型,产前检查时需明确血型,建立特殊血型的预案,在有充足血源及预案的前提下,积极降低产后出血的发生率,保证分娩安全。We report the successful management of a pregnant woman with para-Bombay phenotype.The woman received routine prenatal check-ups and underwent vaginal delivery in the Affiliated Shenzhen Maternity&Child Healthcare Hospital.Blood grouping at 12 weeks of pregnancy showed that the forward typing of the patient was group O,but reverse typing indicated group AB.Her ABO genotype was determined as ABO*A1.02/B.01.There was c.551-552del AG and c.880-882 del TT in the FUT1 gene,and 357C>T and 716G>A in the FUT2 gene.Thus,her FUT1 genotype was h1/h2 and FUT2 genotype was Se/Se.No significant abnormalities were found in the routine prenatal examination.A male infant was born vaginally at 39+2 gestational weeks,who was grouped as B-positive without neonatal hemolytic disease.Para-Bombay is a rare blood group.It is necessary to clarify the blood type during prenatal examination and develop a management strategy for those with special blood groups to reduce the incidence of postpartum hemorrhage and ensure safe delivery.

关 键 词：ABO血型系统 输血 产前保健 

分 类 号：R714.2[医药卫生—妇产科学]