不同TNM分期肺癌患者血清D-D、FIB、APTT的水平变化  

Changes of serum D-D, FIB and APTT levels in patients with different TNM stages of lung cancer

作　　者：赵论[1] 石默晗 张浩然 贡会源[2] ZHAO Lun;SHI Mohan;ZHANG Haoran;GONG Huiyuan(Department of Oncology,the First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui 233003,China;Department of Thoracic Surgery,the First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui 233003,China)

机构地区：[1]蚌埠医学院第一附属医院肿瘤内科,安徽省蚌埠市233003 [2]蚌埠医学院第一附属医院胸外科,安徽省蚌埠市233003

出　　处：《中南医学科学杂志》2022年第3期395-397,401,共4页Medical Science Journal of Central South China

基　　金：安徽省教育厅重点项目(KJ2020A0575)。

摘　　要：目的 分析肺癌患者血清D二聚体(D-D)、纤维蛋白原(FIB)水平和活化部分凝血酶原时间(APTT)与TNM分期及预后的关系。方法 将80例肺癌患者作为治疗组,根据TNM分期标准分为Ⅰ+Ⅱ期组(23例)、Ⅲ期组(32例)和Ⅳ期组(25例);根据出院后随访预后分为死亡组(n=49)和存活组(n=31)。选取同期健康体检正常的80例作为对照组。比较各组D-D、FIB和APTT水平。结果 治疗组D-D、FIB水平高于对照组,APTT低于存活组(P<0.05)。Ⅳ期组、Ⅲ期组D-D、FIB水平高于Ⅰ+Ⅱ期组,APTT低于Ⅰ+Ⅱ期组(P<0.05);Ⅳ期组D-D、FIB水平高于Ⅲ期组,APTT低于Ⅲ期组(P<0.05)。经Sepearman分析,D-D、FIB水平与肺癌患者TNM分期呈正相关,APTT与肺癌患者TNM分期呈负相关(P<0.05)。死亡组D-D、FIB水平高于存活组,APTT低于存活组(P<0.05)。结论 D-D、FIB水平与肺癌患者TNM分期呈正相关,APTT与肺癌患者TNM分期呈负相关,三者与患者预后密切相关。Aim To analyze the relationship between serum D-dimer(D-D), fibrinogen(FIB), activated partial prothrombin time(APTT) and TNM stage and prognosis in patients with lung cancer. Methods Eighty patients with lung cancer were divided into stage Ⅰ+stage Ⅱ group(n=23), stage Ⅲ group(n=32) and stage Ⅳ group(n=25) according to TNM staging criteria. According to the prognosis, the patients were divided into death group(n=49) and survival group(n=31). In the same period, 80 cases with normal physical examination in our hospital were taken as the control group. The levels of D-D, FIB and APTT in each group were compared. Results The levels of D-D and FIB in the treatment group were higher than those of the control group, and APTT was lower than that of the control group(P<0.05). The levels of D-D and FIB in the stage IV and stage III groups were higher than those in the stage I+II group, and the APTT was lower than that in the stage I+II group(P<0.05). The levels of D-D and FIB in stage IV were higher than those in stage III group, and APTT was lower than that in stage III group(P<0.05). According to Sepearman’s analysis, D-D and FIB levels had a positive correlation with TNM staging of lung cancer patients, while APTT had a negative correlation with TNM staging of lung cancer patients(P<0.05). The expression levels of D-D and FIB in the survival group were higher than those in the survival group, and APTT was lower than that in the survival group(P<0.05). Conclusion The levels of D-D and FIB are positively correlated with TNM stage in lung cancer patients, while APTT is negatively correlated with TNM stage in lung cancer patients, and their abnormal expression are closely related to the prognosis of patients.

关 键 词：肺癌 TNM分期 D二聚体 纤维蛋白原 活化部分凝血酶原时间 

分 类 号：R446.11[医药卫生—诊断学]