衡阳地区HCV基因型分布特征及DAA应用的疗效观察  

Genotype distribution of HCV in Hengyang area and therapeutic effect observation of DAA application

作　　者：李擎 李红梅 雷小勇 彭忠田 LI Qing;LI Hongmei;LEI Xiaoyong;PENG Zhongtian(Institute of Pharmacy,the First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,Hunan 421001,China;Liver Disease Research Center,the First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,Hunan 421001,China)

机构地区：[1]南华大学衡阳医学院药学院,湖南省衡阳市421001 [2]南华大学衡阳医学院附属第一医院肝病研究中心,湖南省衡阳市421001

出　　处：《中南医学科学杂志》2022年第3期432-434,共3页Medical Science Journal of Central South China

摘　　要：目的 了解衡阳地区丙型肝炎病毒(HCV)基因型分布特征,观察直接抗病毒药物(DAA)对不同基因型丙型肝炎的治疗效果。方法 对衡阳地区1 148例HCV患者进行基因分型检测及分析,并对133例应用DAA治疗的慢性丙型肝炎患者定期进行血清病毒含量和生化指标检测,观察不同基因型患者抗病毒治疗的应答情况。结果 衡阳地区检测出4种HCV基因型(1、2、3、6)和7种基因亚型(1a、1b、2a、3a、3b、6a、6n),以1b型为主。在DAA治疗的HCV患者中,1b型和非1b型获得的病毒学应答率分别为98.78%和100.00%;生化学应答率均为100.00%。结论 衡阳地区HCV感染以1b型为主,且女性高于男性,年龄≥50岁患者高于年龄<50岁患者。DAA治疗不同基因型慢性HCV均能获得高持续病毒学应答,且疗效显著。Aim To investigate the distribution of Hepatitis C virus genotypes in Hengyang, and to observe the therapeutic effect of direct antiviral agents on different genotypes of Hepatitis C. Methods Genotyping of 1 148 cases of HCV patients in Hengyang area was detected and analyzed, and 133 cases of chronic hepatitis C patients with DAA treatment received regular detection of serum virus content and biochemical indicators, to observe the response of different genotypes of patients with antiviral treatment. Results Four HCV genotypes(1, 2, 3, 6) and seven genotypes(1 a, 1 b, 2 a, 3 a, 3 b, 6 a, 6 n) were detected in Hengyang district, Mainly type 1 b. In DAA-treated HCV patients, the virological response rates obtained for type 1 B and non-1 B patients were 98.78% and 100.00%, respectively. The biochemical response rates were 100.00%. Conclusion HCV infection in Hengyang area is mainly type 1 B, and the female is higher than the male, the age ≥50 years of patients is higher than the age <50 years of patients. DAA treatment of different genotypes of chronic HCV can obtain high sustained virology response, and the efficacy is significant.

关 键 词：丙型肝炎病毒 基因型 感染率 直接抗病毒药物 病毒学应答 

分 类 号：R512.63[医药卫生—内科学]